Young Rachel, Lefevre Lucas, Bush Stephen J, Joshi Akshay, Singh Salam Herojeet, Jadhav Santosh Kumar, Dhanikachalam Velu, Lisowski Zofia M, Iamartino Daniela, Summers Kim M, Williams John L, Archibald Alan L, Gokhale Suresh, Kumar Satish, Hume David A
The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Edinburgh, United Kingdom.
Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom.
Front Genet. 2019 Jul 24;10:668. doi: 10.3389/fgene.2019.00668. eCollection 2019.
The domestic water buffalo () makes a major contribution to the global agricultural economy in the form of milk, meat, hides, and draught power. The global water buffalo population is predominantly found in Asia, and per head of population more people depend upon the buffalo than on any other livestock species. Despite its agricultural importance, there are comparatively fewer genomic and transcriptomic resources available for buffalo than for other livestock species. We have generated a large-scale gene expression atlas covering multiple tissue and cell types from all major organ systems collected from three breeds of riverine water buffalo (Mediterranean, Pandharpuri and Bhadawari) and used the network analysis tool Graphia Professional to identify clusters of genes with similar expression profiles. Alongside similar data, we and others have generated for ruminants as part of the Functional Annotation of Animal Genomes Consortium; this comprehensive transcriptome supports functional annotation and comparative analysis of the water buffalo genome.
家水牛（）以牛奶、肉类、皮革和役力的形式对全球农业经济做出了重大贡献。全球水牛种群主要分布在亚洲，按人口计算，依赖水牛的人数比依赖其他任何家畜物种的人数都多。尽管水牛在农业上具有重要意义，但与其他家畜物种相比，可用于水牛的基因组和转录组资源相对较少。我们已经生成了一个大规模的基因表达图谱，涵盖了从三种河流型水牛（地中海水牛、潘德哈普里水牛和巴达瓦里水牛）收集的所有主要器官系统的多种组织和细胞类型，并使用网络分析工具Graphia Professional来识别具有相似表达谱的基因簇。除了我们和其他人作为动物基因组功能注释联盟的一部分为反刍动物生成的类似数据之外，这个全面的转录组还支持对水牛基因组的功能注释和比较分析。
