结核分枝杆菌对10种抗菌药物的体外敏感性
In vitro susceptibilities of Mycobacterium tuberculosis to 10 antimicrobial agents.
作者信息
Byrne S K, Crawford C E, Geddes G L, Black W A
机构信息
Provincial Laboratory, British Columbia Centre for Disease Control, Vancouver, Canada.
出版信息
Antimicrob Agents Chemother. 1988 Sep;32(9):1441-2. doi: 10.1128/AAC.32.9.1441.
Abstract
After preliminary in vitro screening of 10 antimicrobial agents against Mycobacterium tuberculosis, the MICs of the 6 most promising agents against 27 clinical isolates were determined by agar dilution. The two quinolone compounds tested (difloxacin and A-56620) were the most active, each inhibiting 50% of the strains at concentrations of 4 micrograms/ml. M. tuberculosis strains previously shown to be resistant to isoniazid, streptomycin, rifampin, or ethambutol were as susceptible to these quinolone compounds as susceptible strains.
摘要
在对10种抗结核分枝杆菌的抗菌剂进行初步体外筛选后，通过琼脂稀释法测定了6种最有前景的抗菌剂对27株临床分离株的最低抑菌浓度（MIC）。所测试的两种喹诺酮类化合物（二氟沙星和A-56620）活性最高，在浓度为4微克/毫升时，每种化合物均可抑制50%的菌株。先前已显示对异烟肼、链霉素、利福平或乙胺丁醇耐药的结核分枝杆菌菌株对这些喹诺酮类化合物的敏感性与敏感菌株相同。
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