环丙沙星及其他4-喹诺酮类药物对结核分枝杆菌和胞内分枝杆菌的体外活性比较
Comparative in vitro activities of ciprofloxacin and other 4-quinolones against Mycobacterium tuberculosis and Mycobacterium intracellulare.
作者信息
Fenlon C H, Cynamon M H
出版信息
Antimicrob Agents Chemother. 1986 Mar;29(3):386-8. doi: 10.1128/AAC.29.3.386.
Abstract
The in vitro activity of ciprofloxacin, ofloxacin, amifloxacin, and norfloxacin against 22 clinical isolates of Mycobacterium tuberculosis was evaluated by agar dilution. The MICs for 90% of the isolates of ciprofloxacin and ofloxacin were 0.5 and 1 microgram/ml, respectively. Amifloxacin and norfloxacin were less active. The MICs for 90% of the isolates of ciprofloxacin and ofloxacin against 20 clinical isolates of Mycobacterium intracellulare were determined by agar dilution to be 2 and 8 micrograms/ml, respectively.
摘要
采用琼脂稀释法评估了环丙沙星、氧氟沙星、阿米氟沙星和诺氟沙星对22株临床分离结核分枝杆菌的体外活性。环丙沙星和氧氟沙星对90%分离株的最低抑菌浓度（MIC）分别为0.5和1微克/毫升。阿米氟沙星和诺氟沙星的活性较低。采用琼脂稀释法测定环丙沙星和氧氟沙星对20株细胞内分枝杆菌临床分离株90%分离株的MIC分别为2和8微克/毫升。
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本文引用的文献
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The pharmacokinetics and tissue penetration of ofloxacin.氧氟沙星的药代动力学和组织穿透性。 （注：原文中多了一个of，正确表述应该是The pharmacokinetics and tissue penetration of ofloxacin ）
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