铜绿假单胞菌对头孢吡肟、头孢他啶和头孢噻肟的体外耐药频率。
Frequency of in vitro resistance of Pseudomonas aeruginosa to cefepime, ceftazidime, and cefotaxime.
作者信息
Fung-Tomc J, Huczko E, Pearce M, Kessler R E
机构信息
Department of Microbiology, Bristol-Myers Co., Wallingford, Connecticut 06492.
出版信息
Antimicrob Agents Chemother. 1988 Sep;32(9):1443-5. doi: 10.1128/AAC.32.9.1443.
Abstract
The selection frequencies of cefepime (BMY 28142), ceftazidime, and cefotaxime resistance among Pseudomonas aeruginosa strains were determined. Cefepime-resistant mutants were not selected by cefepime (frequency, less than 10(-11)). Ceftazidime- and cefotaxime-resistant mutants were isolated at frequencies of 10(-5) to 10(-10) and were often cross-resistant. However, cefepime resistance among ceftazidime- and cefotaxime-resistant mutants was rare. Selected mutants resistant to cefepime constitutively produced 40- to 450-fold more beta-lactamase than did the parent strain.
摘要
测定了铜绿假单胞菌菌株中头孢吡肟（BMY 28142）、头孢他啶和头孢噻肟耐药性的选择频率。头孢吡肟未筛选出头孢吡肟耐药突变体（频率小于10^(-11)）。头孢他啶和头孢噻肟耐药突变体的分离频率为10^(-5)至10^(-10)，且常常具有交叉耐药性。然而，头孢他啶和头孢噻肟耐药突变体中头孢吡肟耐药性很罕见。筛选出的对头孢吡肟耐药的突变体组成性产生的β-内酰胺酶比亲本菌株多40至450倍。
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