大肠杆菌对头孢菌素3'-喹诺酮酯Ro 23-9424的低水平耐药性。
Low-level resistance to the cephalosporin 3'-quinolone ester Ro 23-9424 in Escherichia coli.
作者信息
Chapman J S, Bertasso A, Cummings L M, Georgopapadakou N H
机构信息
Roche Research Center, Nutley, New Jersey 07110, USA.
出版信息
Antimicrob Agents Chemother. 1995 Feb;39(2):564-6. doi: 10.1128/AAC.39.2.564.
Abstract
Four spontaneous, single-step mutants of Escherichia coli K-12 resistant to low levels of the cephalosporin 3'-quinolone ester Ro 23-9424 were isolated at a frequency of 10(-10) to 10(-11) mutants per CFU plated. The mutants were cross-resistant to both cephalosporin (cefotaxime) and quinolone (fleroxacin) components. Accordingly, they had altered porins and replicative DNA biosynthesis resistant to fleroxacin. There was no increase in beta-lactamase activity when tested with nitrocephin, and the penicillin-binding protein profiles were normal.
摘要
以每平板接种的CFU产生10⁻¹⁰至10⁻¹¹个突变体的频率，分离出了4株对低水平头孢菌素3'-喹诺酮酯Ro 23-9424具有抗性的大肠杆菌K-12自发单步突变体。这些突变体对头孢菌素（头孢噻肟）和喹诺酮（氟罗沙星）成分均具有交叉抗性。因此，它们的孔蛋白发生了改变，并且复制性DNA生物合成对氟罗沙星具有抗性。用硝噻吩检测时，β-内酰胺酶活性没有增加，青霉素结合蛋白谱正常。
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本文引用的文献
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Antimicrob Agents Chemother. 1993 Mar;37(3):559-65. doi: 10.1128/AAC.37.3.559.
2
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Antimicrob Agents Chemother. 1980 Jul;18(1):148-57. doi: 10.1128/AAC.18.1.148.
3
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J Bacteriol. 1984 Jun;158(3):1041-7. doi: 10.1128/jb.158.3.1041-1047.1984.
4
Gene envY of Escherichia coli K-12 affects thermoregulation of major porin expression.大肠杆菌K-12的envY基因影响主要孔蛋白表达的温度调节。
J Bacteriol. 1984 Jan;157(1):262-8. doi: 10.1128/jb.157.1.262-268.1984.
5
Porin channels in Escherichia coli: studies with beta-lactams in intact cells.大肠杆菌中的孔蛋白通道：在完整细胞中使用β-内酰胺类药物的研究
J Bacteriol. 1983 Jan;153(1):232-40. doi: 10.1128/jb.153.1.232-240.1983.
6
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J Bacteriol. 1984 Aug;159(2):555-63. doi: 10.1128/jb.159.2.555-563.1984.
7
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Proc Natl Acad Sci U S A. 1970 Oct;67(2):674-81. doi: 10.1073/pnas.67.2.674.
8
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9
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