Department of Dental Clinical Specialities, School of Dentistry, Madrid, Spain, Plaza Ramón y Cajal s/n, 28040 Madrid, Spain,
Med Oral Patol Oral Cir Bucal. 2019 Sep 1;24(5):e652-e658. doi: 10.4317/medoral.22973.
The aim of this study was to assess the effect of local application of IGF-I on osseointegration of dental implants placed in osteoporotic bones.
16 rabbits were randomly distributed into two groups: eight animals were ovariectomized and fed a low-calcium diet for six weeks, in order to induce experimental osteoporosis, and the others were sham-operated and fed a standard diet. A titanium implant was inserted into the tibiae in both groups. In half of the rabbits, 4 μg of IGF-I was applied into the ostectomy, prior to the implant insertion. A total of 32 implants were placed. Animals were sacrificed two weeks after surgery and decalcified samples were processed for Bone-To-Implant Contact (BIC) and Bone Area Density (BAD) measurements. Analysis of variance (ANOVA) was used for statistical evaluation. P<0.05 was considered to be significant.
Ovariectomy induced statistically significant lower BAD values (p=0.008) and a tendency towards lower BIC values when compared osteoporotic and healthy groups. The administration of 4 μg of IGF-I did not produce statistically significant differences neither on BIC nor on BAD values, neither in the osteoporotic animals nor in healthy.
Within the limitations of this experimental study, local administration of 4 μg of IGF-I was not able to induce any changes in the osseointegration process two weeks after surgery, neither in healthy rabbits nor in the osteoporotic group.
本研究旨在评估局部应用 IGF-I 对骨质疏松性骨中种植体骨整合的影响。
16 只兔子被随机分为两组：8 只动物行卵巢切除术并给予低钙饮食 6 周，以诱导实验性骨质疏松症，其余动物行假手术并给予标准饮食。两组均将钛种植体插入胫骨。在一半兔子中，在插入种植体之前，将 4μg IGF-I 应用于骨切除部位。共放置 32 个种植体。手术后 2 周处死动物，对脱钙样本进行骨-种植体接触（BIC）和骨面积密度（BAD）测量。采用方差分析（ANOVA）进行统计学评价。P<0.05 被认为具有统计学意义。
卵巢切除术导致 BAD 值显著降低（p=0.008），且与骨质疏松组和健康组相比，BIC 值有降低趋势。给予 4μg IGF-I 后，无论是在骨质疏松动物还是健康动物中，BIC 和 BAD 值均无统计学差异。
在本实验研究的限制范围内，局部给予 4μg IGF-I 不能在手术后 2 周内改变骨整合过程，无论是在健康兔子还是骨质疏松组中均如此。
