Saw Swee Hock School of Public Health, National University Health System, Singapore, Singapore.
Department of Neurology, Program in Occupational Therapy, Washington University in St Louis, St. Louis, Missouri, USA.
Cerebrovasc Dis. 2019;47(5-6):291-298. doi: 10.1159/000502278. Epub 2019 Aug 21.
This paper aims to describe and compare the characteristics of 2 stroke populations in Singapore and in St. Louis, USA, and to document thrombolysis rates and contrast factors associated with its uptake in both populations.
The stroke populations described were from the Singapore Stroke Registry (SSR) in -Singapore and the Cognitive Rehabilitation Research Group Stroke Registry (CRRGSR) in St. Louis, MO, USA. The registries were compared in terms of demographics and stroke risk factor history. Logistic regression was used to determine factors associated with thrombolysis uptake.
A total of 39,323 and 8,106 episodes were recorded in SSR and CRRGSR, respectively, from 2005 to 2012. Compared to CRRGSR, patients in SSR were older, male, and from the ethnic majority. Thrombolysis rates in SSR and CRRGSR were 2.5 and 8.2%, respectively, for the study period. History of ischemic heart disease or atrial fibrillation was associated with increased uptake in both populations, while history of stroke was associated with lower uptake. For SSR, younger age and males were associated with increased uptake, while having a history of smoking or diabetes was associated with decreased uptake. For CRRGSR, ethnic minority status was associated with decreased uptake.
The comparison of stroke populations in Singapore and St Louis revealed distinct differences in clinicodemographics of the 2 groups. Thrombolysis uptake was driven by nonethnicity demographics in Singapore. Ethnicity was the only demographic driver of uptake in the CRRGSR population, highlighting the need to target ethnic minorities in increasing access to thrombolysis.
本文旨在描述和比较新加坡和美国密苏里州圣路易斯的两个卒中人群的特征，并记录溶栓治疗的比例以及两个人群中与溶栓治疗相关的因素。
本文描述的卒中人群来自新加坡卒中登记处（SSR）和美国密苏里州圣路易斯认知康复研究组卒中登记处（CRRGSR）。这两个登记处从人口统计学和卒中危险因素史方面进行了比较。采用 logistic 回归确定与溶栓治疗相关的因素。
2005 年至 2012 年，SSR 和 CRRGSR 分别记录了 39323 例和 8106 例卒中发作。与 CRRGSR 相比，SSR 中的患者年龄较大、男性比例较高、来自主要种族。SSR 和 CRRGSR 在研究期间的溶栓治疗比例分别为 2.5%和 8.2%。缺血性心脏病或心房颤动史与两个人群的溶栓治疗使用率增加有关，而卒中史与溶栓治疗使用率降低有关。对于 SSR，年龄较小和男性与溶栓治疗使用率增加有关，而吸烟或糖尿病史与溶栓治疗使用率降低有关。对于 CRRGSR，少数民族身份与溶栓治疗使用率降低有关。
新加坡和圣路易斯卒中人群的比较揭示了两组人群在临床特征方面的显著差异。新加坡溶栓治疗的使用率取决于非种族人口统计学因素。种族是 CRRGSR 人群中唯一与溶栓治疗使用率相关的人口统计学因素，这突出表明需要针对少数民族，以增加其获得溶栓治疗的机会。
