Liu A Q, Chen W
Department of Cancer Epidemiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China.
Zhonghua Zhong Liu Za Zhi. 2019 Aug 23;41(8):561-564. doi: 10.3760/cma.j.issn.0253-3766.2019.08.001.
Esophagus, as the pipe connecting oral cavity and stomach, has unique anatomical structure and physiological functions. The related diseases including esophageal cancer and precancerous lesions are the ones of major public health problems in China. The pathogenesis of esophageal diseases is still not clear. The exploration of correlation between the changes of esophageal microbiota and esophageal diseases becomes a new breakthrough in the study of etiology. Previous studies have found enrichment of gram-positive bacteria in the normal esophagus, while a decrease in diversity of bacteria and a dominant gram-negative anaerobe in diseased esophagus. Although much progress has been made in the study of esophageal microbiota, the standard method of how to accurately and noninvasively collect esophageal microbiota is still lack, which is an important part of the esophageal microbial research.
食管作为连接口腔和胃的管道，具有独特的解剖结构和生理功能。包括食管癌和癌前病变在内的相关疾病是中国主要的公共卫生问题之一。食管疾病的发病机制仍不清楚。探索食管微生物群变化与食管疾病之间的相关性成为病因学研究的一个新突破。先前的研究发现，正常食管中革兰氏阳性菌富集，而患病食管中细菌多样性降低且革兰氏阴性厌氧菌占主导。尽管食管微生物群的研究取得了很大进展，但仍缺乏如何准确、无创地收集食管微生物群的标准方法，这是食管微生物研究的重要组成部分。
