Department of Chemistry, Indian Institute of Technology Bombay, Powai, 400076, India.
J Membr Biol. 2019 Oct;252(4-5):213-226. doi: 10.1007/s00232-019-00087-0. Epub 2019 Aug 21.
Biological membranes display a staggering complexity of lipids and proteins orchestrating cellular functions. Superior analytical tools coupled with numerous functional cellular screens have enabled us to query their role in cellular signalling, trafficking, guiding protein structure and function-all of which rely on the dynamic membrane lipid properties indispensable for proper cellular functions. Alteration of these has led to emergence of various pathological conditions, thus opening an area of lipid-centric therapeutic approaches. This perspective is a short summary of the dynamic properties of membranes essential for proper cellular functions, dictating both protein and lipid functions, and mis-regulated in diseases. Towards the end, we focus on some challenges lying ahead and potential means to tackle the same, mainly underscored by multi-disciplinary approaches.
生物膜呈现出令人惊叹的脂质和蛋白质的复杂性，这些物质协调着细胞的功能。优越的分析工具和众多功能细胞筛选使我们能够研究它们在细胞信号转导、运输、引导蛋白质结构和功能中的作用——所有这些都依赖于动态膜脂质特性，而这些特性对于正常的细胞功能是不可或缺的。这些特性的改变导致了各种病理状况的出现，从而开辟了以脂质为中心的治疗方法的领域。本文简要概述了对正常细胞功能至关重要的膜的动态特性，这些特性决定了蛋白质和脂质的功能，并在疾病中失调。最后，我们将重点讨论一些摆在面前的挑战和潜在的解决方法，主要强调多学科方法。
