Olyhoek T, Crowe B A, Wall R A, Achtman M
Max Planck Institut für molekulare Genetik, West Berlin.
Microb Pathog. 1988 Jan;4(1):45-51. doi: 10.1016/0882-4010(88)90047-2.
We have formerly described a clonal analysis of 423 serogroup A isolates of Neisseria meningitidis which distinguished 21 clones and 34 electrophoretic types. The clones were found to be uniform within distinct epidemiological situations and distinct between different sets of epidemics. Strains representative of the 34 electrophoretic types have now been analyzed by restriction endonuclease digestion of their genomic DNA's. The results correlated partially with the clonal assignments; the discrepancies were epidemiologically more consistent with the interpretation of the clonal analysis than with that of the restriction endonuclease analysis.
我们之前描述了对423株A群脑膜炎奈瑟菌的克隆分析，该分析区分出了21个克隆和34种电泳类型。发现这些克隆在不同的流行病学情况下是一致的，而在不同的疫情组之间是不同的。现在已通过对代表34种电泳类型的菌株的基因组DNA进行限制性内切酶消化分析。结果与克隆分类部分相关；这些差异在流行病学上与克隆分析的解释比与限制性内切酶分析的解释更一致。
