Department of Human Development and Family Studies, College of Human Sciences, Texas Tech University, 1301 Akron Street, Box 1230, Lubbock, TX, 79409-1230, USA.
Department of Psychiatry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
J Autism Dev Disord. 2019 Dec;49(12):4751-4760. doi: 10.1007/s10803-019-04187-7.
Evidence on neurophysiological correlates of coexisting autism spectrum disorders (ASD) and overweight/obesity may elucidate mechanisms leading to the observed greater risk of obesity in children with ASD. An exploratory secondary data analysis was performed on resting state functional magnetic resonance imaging (rs-fMRI) data of children downloaded from the ABIDE Preprocessed database (n = 81). Children with isolated ASD showed hypo-connectivity between anterior and posterior default mode network (DMN) (p = 0.003; FWER). Children with coexisting ASD and overweight/obesity showed hyper-connectivity between anterior and posterior DMN (p = 0.015; FWER). More evidence is needed to confirm these contrasting rs-fMRI connectivity profiles and to explicate causal inferences regarding neurophysiological mechanisms associated with coexisting ASD and overweight/obesity.
关于共存自闭症谱系障碍（ASD）和超重/肥胖的神经生理相关性的证据，可以阐明导致 ASD 儿童肥胖风险增加的机制。对从 ABIDE 预处理数据库下载的儿童静息状态功能磁共振成像（rs-fMRI）数据进行了探索性二次数据分析（n=81）。患有孤立性 ASD 的儿童在前后默认模式网络（DMN）之间表现出连接不足（p=0.003；FWER）。共存 ASD 和超重/肥胖的儿童在前后 DMN 之间表现出过度连接（p=0.015；FWER）。需要更多的证据来证实这些对比的 rs-fMRI 连接模式，并阐明与共存 ASD 和超重/肥胖相关的神经生理机制的因果推论。
