Shigemoto Yoko, Sone Daichi, Ota Miho, Maikusa Norihide, Ogawa Masayo, Okita Kyoji, Takano Harumasa, Kato Koichi, Kimura Yukio, Morimoto Emiko, Suzuki Fumio, Fujii Hiroyuki, Sato Noriko, Matsuda Hiroshi
Integrative Brain Imaging Center, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
Department of Radiology, National Center of Neurology and Psychiatry, 4-1-1, Ogawa-Higashi, Kodaira, Tokyo, 187-8551, Japan.
EJNMMI Res. 2019 Aug 23;9(1):81. doi: 10.1186/s13550-019-0552-3.
Although neurofibrillary tangles (NFTs) mainly accumulate in the medial temporal lobe with human aging, only a few imaging studies have investigated correlations between NFT accumulation and gray matter (GM) volume in cognitively normal older adults. Here, we investigated the correlations between F-THK5351 accumulation and GM volume at the voxel level.
We recruited 47 amyloid-negative, cognitively normal, older adults (65.0 ± 7.9 years, 26 women), who underwent structural magnetic resonance imaging, C-Pittsburgh compound-B and F-THK5351 PET scans, and neuropsychological assessment. The magnetic resonance and F-THK5351 PET images were spatially normalized using Statistical Parametric Mapping 12. Voxel-wise correlations between F-THK5351 accumulation and GM volume were evaluated using the Biological Parametric Mapping toolbox.
A significant negative correlation (p < 0.001) between F-THK5351 accumulation and GM volume was detected in the bilateral medial temporal lobes.
Voxel-wise correlation analysis revealed a significant negative correlation between F-THK5351 accumulation and GM volume in the medial temporal lobe in individuals without amyloid-β deposits. These results may contribute to a better understanding of the pathophysiology of primary age-related tauopathy in human aging.
尽管神经原纤维缠结（NFTs）主要随人类衰老而在内侧颞叶积累，但仅有少数影像学研究调查了认知正常的老年人中NFT积累与灰质（GM）体积之间的相关性。在此，我们在体素水平上研究了F-THK5351积累与GM体积之间的相关性。
我们招募了47名淀粉样蛋白阴性、认知正常的老年人（65.0±7.9岁，26名女性），他们接受了结构磁共振成像、C-匹兹堡化合物B和F-THK5351正电子发射断层扫描（PET）以及神经心理学评估。使用统计参数映射12对磁共振和F-THK5351 PET图像进行空间归一化。使用生物参数映射工具箱评估F-THK5351积累与GM体积之间的体素级相关性。
在双侧内侧颞叶中检测到F-THK5351积累与GM体积之间存在显著负相关（p<0.001）。
体素级相关性分析显示，在没有淀粉样β沉积的个体中，内侧颞叶的F-THK5351积累与GM体积之间存在显著负相关。这些结果可能有助于更好地理解人类衰老过程中原发性年龄相关性tau蛋白病的病理生理学。
