用分析超速离心法对G-四链体结构与结合进行新的研究
Putting a New Spin of G-Quadruplex Structure and Binding by Analytical Ultracentrifugation.
作者信息
Dean William L, Gray Robert D, DeLeeuw Lynn, Monsen Robert C, Chaires Jonathan B
机构信息
James Graham Brown Cancer Center, University of Louisville, Louisville, KY, USA.
出版信息
Methods Mol Biol. 2019;2035:87-103. doi: 10.1007/978-1-4939-9666-7_5.
PMID:31444745
Abstract
Analytical ultracentrifugation is a powerful biophysical tool that provides information about G-quadruplex structure, stability, and binding reactivity. This chapter provides a simplified explanation of the method, along with examples of how it can be used to characterize G4 formation and to monitor small-molecule binding.
摘要
分析超速离心是一种强大的生物物理工具，可提供有关G-四链体结构、稳定性和结合反应性的信息。本章对该方法进行了简化说明，并举例说明了如何用它来表征G4的形成以及监测小分子结合。
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