Holmstrup P, Thorn J J, Rindum J, Pindborg J J
Institute of Oral Pathology and Oral Medicine, Royal Dental College, Copenhagen, Denmark.
J Oral Pathol. 1988 May;17(5):219-25. doi: 10.1111/j.1600-0714.1988.tb01528.x.
The present report describes malignant development in oral lichen planus (OLP) among 611 patients (409 F, 202 M) followed for periods from 1-26 years (mean: 7.5). During follow-up, 9 patients (1.5%), 8 women (1.9%) and 1 man (0.5%) developed oral squamous cell carcinomas (SCC) in areas of lichen planus lesions. The age of the patients at diagnosis of carcinoma ranged from 56-79 years (mean: 70.4) and the length of follow-up before malignant development ranged from 4.9-24 years (mean: 10.1). The estimated number expected to develop oral cancer in a sample of the general Danish population of similar size, age distribution and follow-up was 0.18 (0.11 F, 0.07 M) i.e., OLP cases showed a 50-fold increase (F = 70- M = 14-fold). The observed number of cancer cases was significantly higher than the estimated number (p less than 0.00001). Therefore, oral lichen planus fulfils the WHO criterion of a premalignant condition.
本报告描述了611例患者（409例女性，202例男性）口腔扁平苔藓（OLP）的恶变情况，随访时间为1至26年（平均7.5年）。随访期间，9例患者（1.5%）发生恶变，其中8例女性（1.9%）和1例男性（0.5%）在扁平苔藓病变区域发生了口腔鳞状细胞癌（SCC）。确诊癌症时患者的年龄在56至79岁之间（平均70.4岁），恶变前的随访时间在4.9至24年之间（平均10.1年）。在丹麦普通人群中，选取规模、年龄分布和随访情况相似的样本，预计发生口腔癌的人数为0.18（女性0.11例，男性0.07例），即OLP患者发生口腔癌的几率增加了50倍（女性为70倍，男性为14倍）。观察到的癌症病例数显著高于预期数（p<0.00001）。因此，口腔扁平苔藓符合世界卫生组织关于癌前病变的标准。
