Wan Qing-Song, Li Li, Yang Shi-Kun, Liu Zi-Long, Song Na
Department of Nephrology, The First Affiliated Hospital of the University of South China, Hengyang, China.
Department of Medicine, Hunan Environment-Biological Polytechnic, Hengyang, China.
Genet Test Mol Biomarkers. 2019 Sep;23(9):618-633. doi: 10.1089/gtmb.2019.0021. Epub 2019 Aug 26.
To assess whether vitamin D receptor () gene polymorphisms influence the susceptibility to periodontitis. We retrieved 34 relevant studies, comprising a total of 3848 subjects suffering from periodontitis and 3470 controls for this meta-analysis. The pooled data were analyzed using STATA software. Among all ethnic groups examined, the I polymorphism was associated with periodontitis under the recessive model (odds ratio [OR] = 0.722, 95% confidence interval [CI]: 0.532-0.980, = 0.037). There was also a link between the I polymorphism and periodontitis in the overall population (dominant model: OR = 1.459, 95% CI: 1.050-2.028, = 0.025 and allelic model: OR = 1.386, 95% CI: 1.026-1.874, = 0.034) and in Chinese participants (dominant model: OR = 1.813, 95% CI: 1.185-2.774, = 0.006; allelic model: OR = 1.602, 95% CI: 1.044-2.459, = 0.031) when stratified by race. The I variant was also correlated with aggressive periodontitis (AP) (dominant model: OR = 2.204, 95% CI: 1.148-4.231, = 0.018; allelic model: OR = 2.017, 95% CI: 1.365-2.980, = 0.000; and recessive model: OR = 2.903, 95% CI: 1.520-5.542, = 0.001). We also showed a correlation between the I variant and periodontitis susceptibility in Caucasian populations (dominant model: OR = 0.525, 95% CI: 0.318-0.866, = 0.012). The results revealed that there was no relationship between the I gene polymorphism and periodontitis. There was a link between the I and I gene polymorphisms and periodontitis in the overall population. In addition, the I polymorphism was correlated with AP. There was a link between the I polymorphism and periodontitis in the Caucasian population. The variant, however, was not correlated with periodontitis.
为评估维生素D受体（）基因多态性是否影响患牙周炎的易感性。我们检索了34项相关研究，共纳入3848例牙周炎患者和3470例对照进行这项荟萃分析。使用STATA软件对汇总数据进行分析。在所有检测的种族群体中，在隐性模型下，I基因多态性与牙周炎相关（比值比[OR] = 0.722，95%置信区间[CI]：0.532 - 0.980， = 0.037）。在总体人群中（显性模型：OR = 1.459，95% CI：1.050 - 2.028， = 0.025；等位基因模型：OR = 1.386，95% CI：1.026 - 1.874， = 0.034）以及在中国参与者中（显性模型：OR = 1.813，95% CI：1.185 - 2.774， = 0.006；等位基因模型：OR = 1.602，95% CI：1.044 - 2.459， = 0.031），按种族分层时，I基因多态性也与牙周炎有关。I变异型也与侵袭性牙周炎（AP）相关（显性模型：OR = 2.204，95% CI：1.148 - 4.231， = 0.018；等位基因模型：OR = 2.017，95% CI：1.365 - 2.980， = 0.000；隐性模型：OR = 2.903，95% CI：1.520 - 5.542， = 0.001）。我们还显示在白种人群中I变异型与牙周炎易感性之间存在相关性（显性模型：OR = 0.525，95% CI：0.318 - 0.866， = 0.012）。结果显示I基因多态性与牙周炎之间无关联。在总体人群中，I和I基因多态性与牙周炎有关。此外，I基因多态性与AP相关。在白种人群中，I基因多态性与牙周炎有关。然而，变异型与牙周炎无相关性。
