The Impact of Vitamin D Receptor Gene Polymorphisms on the Susceptibility of Diabetic Vascular Complications: A Meta-Analysis.

To determine whether vitamin D receptor () gene polymorphisms are correlated with susceptibility to diabetic vascular complications. We included all eligible studies, and used Stata12.0 to calculate the pooled results. Eight thousand eleven diabetic patients and 1635 normal controls from 27 studies were included. Our results showed that there was no correlation between gene I variants and diabetic nephropathy (DN) or diabetic retinopathy (DR) susceptibility. In comparison with diabetic patients without DN, there was a link between the gene I variant and DN susceptibility under allelic model ( = 0.029) in all populations. In addition, the gene I variant correlated with DN under both dominant ( = 0.005) and allelic ( = 0.003) models in Asian populations. The gene I variant was also correlated with DN susceptibility under the recessive model ( = 0.027) in the Asian subgroup. In comparison with diabetic patients without DR, we identified a link between the gene I variant and DR susceptibility under the dominant model ( = 0.034) in all populations. Also, the gene I variant was correlated with DR under the recessive ( = 0.016), the allelic ( = 0.001), and the dominant ( < 0.001) models in all populations. When compared with healthy controls, the gene I variant was associated with DR under the additive ( = 0.014), the allelic ( = 0.033), and the dominant ( < 0.001) models in Indian populations. The gene I, I, and I gene variants are associated with DN and DR susceptibility. No association was found between the gene I gene variants and diabetic vascular complications.