Neto Ana S, Brazete Daniela, Ferreira José M F
Department of Materials and Ceramic Engineering, CICECO, University of Aveiro, 3810-193 Aveiro, Portugal.
Materials (Basel). 2019 Aug 24;12(17):2711. doi: 10.3390/ma12172711.
The combination of calcium phosphates with bioactive glasses (BG) has received an increased interest in the field of bone tissue engineering. In the present work, biphasic calcium phosphates (BCP) obtained by hydrothermal transformation of cuttlefish bone (CB) were coated with a Sr-, Mg- and Zn-doped sol-gel derived BG. The scaffolds were characterized by X-ray diffraction, Fourier transform infrared spectroscopy and scanning electron microscopy. The initial CB structure was maintained after hydrothermal transformation (HT) and the scaffold functionalization did not jeopardize the internal structure. The results of the in-vitro bioactivity after immersing the BG coated scaffolds in simulated body fluid (SBF) for 15 days showed the formation of apatite on the surface of the scaffolds. Overall, the functionalized CB derived BCP scaffolds revealed promising properties, but further assessment of the in-vitro biological properties is needed before being considered for their use in bone tissue engineering applications.
磷酸钙与生物活性玻璃（BG）的组合在骨组织工程领域受到了越来越多的关注。在本研究中，通过对乌贼骨（CB）进行水热转变获得的双相磷酸钙（BCP）被涂上了一种掺杂了锶、镁和锌的溶胶-凝胶衍生BG。通过X射线衍射、傅里叶变换红外光谱和扫描电子显微镜对支架进行了表征。水热转变（HT）后，初始的CB结构得以保留，并且支架功能化并未损害内部结构。将涂有BG的支架浸入模拟体液（SBF）中15天后的体外生物活性结果表明，支架表面形成了磷灰石。总体而言，功能化的CB衍生BCP支架显示出有前景的性能，但在考虑将其用于骨组织工程应用之前，还需要进一步评估其体外生物学性能。
