Cui Ping, Wang Sicen
School of Pharmacy, Xi'an Jiaotong University Health Science Center, #76, Yanta West Road, Xi'an 710061, China.
Shaanxi Engineering Research Center of Cardiovascular Drugs Screening & Analysis, Xi'an 710061, China.
J Pharm Anal. 2019 Aug;9(4):238-247. doi: 10.1016/j.jpha.2018.12.001. Epub 2018 Dec 6.
The development of pharmaceutical analytical methods represents one of the most significant aspects of drug development. Recent advances in microfabrication and microfluidics could provide new approaches for drug analysis, including drug screening, active testing and the study of metabolism. Microfluidic chip technologies, such as lab-on-a-chip technology, three-dimensional (3D) cell culture, organs-on-chip and droplet techniques, have all been developed rapidly. Microfluidic chips coupled with various kinds of detection techniques are suitable for the high-throughput screening, detection and mechanistic study of drugs. This review highlights the latest (2010-2018) microfluidic technology for drug analysis and discusses the potential future development in this field.
药物分析方法的发展是药物研发最重要的方面之一。微纳加工和微流控技术的最新进展可为药物分析提供新方法，包括药物筛选、活性测试和代谢研究。微流控芯片技术，如芯片实验室技术、三维（3D）细胞培养、器官芯片和微滴技术等均已得到迅速发展。结合各种检测技术的微流控芯片适用于药物的高通量筛选、检测及作用机制研究。本文综述了2010 - 2018年用于药物分析的最新微流控技术，并探讨了该领域未来的潜在发展。
