Wu Limin, Xu Degang, Wang Yuye, Liao Bin, Jiang Zhinan, Zhao Lu, Sun Zhongcheng, Wu Nan, Chen Tunan, Feng Hua, Yao Jianquan
Institute of Laser and Optoelectronics, School of Precision Instruments and Optoelectronics Engineering, Tianjin University, Tianjin 300072, China.
Key Laboratory of Optoelectronic Information Science and Technology (Ministry of Education), Tianjin University, Tianjin 300072, China.
Biomed Opt Express. 2019 Jul 12;10(8):3953-3962. doi: 10.1364/BOE.10.003953. eCollection 2019 Aug 1.
We demonstrated that brain glioma in a mouse model using a continuous-wave terahertz reflection imaging system, as well as the fresh brain tissues in mouse model. The tumor regions of and brain tissues can be well distinguished by THz intensity imaging at the frequency of 2.52THz. The THz images with high sensitivity correlated well with magnetic resonance, visual and hematoxylin and eosin stained images. Furthermore, the THz spectral difference between brain gliomas and normal brain tissues were obtained in the 0.6THz to 2.8THz range, where brain gliomas have the higher refractive indices and absorption coefficients, and their differences increase particularly in the high frequency range. These results suggest that THz imaging has great potential as an alternative method for the intraoperative label-free diagnosis of brain glioma .
我们使用连续波太赫兹反射成像系统在小鼠模型中证明了脑胶质瘤，以及小鼠模型中的新鲜脑组织。在2.52太赫兹频率下通过太赫兹强度成像可以很好地区分肿瘤区域和脑组织。高灵敏度的太赫兹图像与磁共振、视觉和苏木精-伊红染色图像相关性良好。此外，在0.6太赫兹至2.8太赫兹范围内获得了脑胶质瘤与正常脑组织之间的太赫兹光谱差异，其中脑胶质瘤具有更高的折射率和吸收系数，并且它们的差异在高频范围内尤其增大。这些结果表明，太赫兹成像作为脑胶质瘤术中无标记诊断的替代方法具有巨大潜力。
