Xu Kaichen, Zhou Rui, Takei Kuniharu, Hong Minghui
Department of Electrical and Computer Engineering National University of Singapore 4 Engineering Drive 3 Singapore 117576 Singapore.
Department of Physics and Electronics Osaka Prefecture University Sakai Osaka 599-8531 Japan.
Adv Sci (Weinh). 2019 Jul 2;6(16):1900925. doi: 10.1002/advs.201900925. eCollection 2019 Aug 21.
Surface-enhanced Raman scattering (SERS) spectroscopy provides a noninvasive and highly sensitive route for fingerprint and label-free detection of a wide range of molecules. Recently, flexible SERS has attracted increasingly tremendous research interest due to its unique advantages compared to rigid substrate-based SERS. Here, the latest advances in flexible substrate-based SERS diagnostic devices are investigated in-depth. First, the intriguing prospect of point-of-care diagnostics is briefly described, followed by an introduction to the cutting-edge SERS technique. Then, the focus is moved from conventional rigid substrate-based SERS to the emerging flexible SERS technique. The main part of this report highlights the recent three categories of flexible SERS substrates, including actively tunable SERS, swab-sampling strategy, and the in situ SERS detection approach. Furthermore, other promising means of flexible SERS are also introduced. The flexible SERS substrates with low-cost, batch-fabrication, and easy-to-operate characteristics can be integrated into portable Raman spectroscopes for point-of-care diagnostics, which are conceivable to penetrate global markets and households as next-generation wearable sensors in the near future.
表面增强拉曼散射（SERS）光谱为广泛分子的指纹识别和无标记检测提供了一种非侵入性且高度灵敏的途径。近来，与基于刚性基底的SERS相比，柔性SERS因其独特优势而吸引了越来越多的研究兴趣。在此，对基于柔性基底的SERS诊断设备的最新进展进行了深入研究。首先，简要描述了即时诊断的诱人前景，接着介绍了前沿的SERS技术。然后，重点从传统的基于刚性基底的SERS转向新兴的柔性SERS技术。本报告的主要部分突出了近期三类柔性SERS基底，包括主动可调谐SERS、拭子采样策略和原位SERS检测方法。此外，还介绍了其他有前景的柔性SERS手段。具有低成本、批量制造和易于操作特点的柔性SERS基底可集成到便携式拉曼光谱仪中用于即时诊断，在不久的将来有望作为下一代可穿戴传感器打入全球市场并走进千家万户。
