Liu Guoran, Mu Zhimei, Guo Jing, Shan Ke, Shang Xiaoyi, Yu Jing, Liang Xiu
Advanced Materials Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Shandong Artificial Intelligence Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Front Chem. 2022 Nov 3;10:1060322. doi: 10.3389/fchem.2022.1060322. eCollection 2022.
As a powerful and effective analytical tool, surface-enhanced Raman scattering (SERS) has attracted considerable research interest in the fields of wearable flexible sensing and non-invasive point-of-care testing (POCT) medical diagnosis. In this mini-review, we briefly summarize the design strategy, the development progress of wearable SERS sensors and its applications in this field. We present SERS substrate analysis of material design requirements for wearable sensors and highlight the benefits of novel plasmonic particle-in-cavity (PIC)-based nanostructures for flexible SERS sensors, as well as the unique interfacial adhesion effect and excellent mechanical properties of natural silk fibroin (SF) derived from natural cocoons, indicating promising futures for applications in the field of flexible electronic, optical, and electrical sensors. Additionally, SERS wearable sensors have shown great potential in the fields of different disease markers as well as in the diagnosis testing for COVID-19. Finally, the current challenges in this field are pointed out, as well as the promising prospects of combining SERS wearable sensors with other portable health monitoring systems for POCT medical diagnosis in the future.
作为一种强大而有效的分析工具，表面增强拉曼散射（SERS）在可穿戴柔性传感和无创即时检测（POCT）医学诊断领域引起了相当大的研究兴趣。在本综述中，我们简要总结了可穿戴SERS传感器的设计策略、发展进展及其在该领域的应用。我们对可穿戴传感器的材料设计要求进行了SERS基底分析，并强调了基于新型等离子体腔中粒子（PIC）的纳米结构对柔性SERS传感器的益处，以及天然蚕茧衍生的天然丝素蛋白（SF）独特的界面粘附效应和优异的机械性能，这表明其在柔性电子、光学和电气传感器领域具有广阔的应用前景。此外，SERS可穿戴传感器在不同疾病标志物领域以及COVID-19诊断测试中都显示出了巨大潜力。最后，指出了该领域当前面临的挑战，以及未来将SERS可穿戴传感器与其他便携式健康监测系统相结合用于POCT医学诊断的广阔前景。
