University of Ottawa Heart Institute , Ottawa , Ontario K1Y 4W7 , Canada.
ACS Sens. 2019 Oct 25;4(10):2706-2715. doi: 10.1021/acssensors.9b01150. Epub 2019 Aug 27.
Quality control is imperative for since the primary cannabinoids, Δ-tetrahydrocannabinol (THC) and cannabidiol (CBD), elicit very different pharmacological effects. THC/CBD ratios are currently determined by techniques not readily accessible by consumers or dispensaries and which are impractical for use in the field by law-enforcement agencies. CuPc- and F-CuPc-based organic thin-film transistors have been combined with a cannabinoid-sensitive chromophore for the detection and differentiation of THC and CBD. The combined use of these well-characterized and inexpensive p- and n-type materials afforded the determination of the CBD/THC ratio from rapid plant extracts, with results indistinguishable from high-pressure liquid chromatography. Analysis of the prepyrolyzed sample accurately predicted postpyrolysis THC/CBD, which ultimately influences the psychotropic and medicinal effects of the specific plant. The devices were also capable of vapor-phase sensing, producing a unique electrical output for THC and CBD relative to other potentially interfering vaporized organic products. The analysis of complex medicinal plant extracts and vapors, normally reserved for advanced analytical infrastructure, can be achieved with ease, at low cost, and on the spot, using organic thin-film transistors.
质量控制对于大麻至关重要，因为主要的大麻素，Δ-四氢大麻酚（THC）和大麻二酚（CBD），会产生非常不同的药理作用。目前，THC/CBD 比值是通过消费者或药房不易获得的技术来确定的，而且对于执法机构在现场使用来说不切实际。基于 CuPc 和 F-CuPc 的有机薄膜晶体管已与大麻素敏感的生色团结合，用于检测和区分 THC 和 CBD。这些经过良好表征且价格低廉的 p 型和 n 型材料的组合使用，可从快速植物提取物中确定 CBD/THC 比值，其结果与高压液相色谱法无法区分。对预热解样品的分析准确预测了热解后的 THC/CBD，这最终影响了特定植物的致幻和药用效果。这些器件还能够进行气相传感，与其他可能干扰的汽化有机产物相比，产生 THC 和 CBD 的独特电输出。使用有机薄膜晶体管，可以轻松、低成本、现场地分析复杂的药用植物提取物和蒸气，而这些通常需要先进的分析基础设施。
