Enhancing the Integration of Pre-Emptive Pharmacogenetic (PGx) Testing in Primary Care: Prioritizing Underserved Patients' Preferences in Implementation.

: The integration of pharmacogenetic (PGx) testing into primary care has not been widely implemented, despite its benefits for patients and providers. PGx testing could also reduce health disparities as patients with lower healthcare access are prescribed higher proportions of medications with PGx guidelines. Little is known about the preferences of patients who have experienced PGx testing to inform implementation across the care process. This qualitative study aimed to refine implementation by capturing patient preferences on (1) testing and prescription timing, (2) patient-clinician discussion of results during post-test counseling, and (3) usability of a card during results dissemination. : Interviews were conducted with 25 primary care patients from clinics primarily serving medically underserved populations. Interview transcripts were thematically analyzed using a constant comparative approach. : While patients supported both reactive and pre-emptive testing, they valued pre-emptive PGx testing because it is , , and is . Patients' preferences for receiving prescriptions depended on several factors: , , and . Patients identified three issues critical to patient-clinician interactions when receiving testing results: , , and . Lastly, they liked that the results card could and but said it lacked . : These findings should inform implementation strategies for integrating PGx testing in primary care for underserved patients.