Massmann Amanda, Baye Jordan, Weaver Max, Petry Natasha, Jacobsen Kristen, Schultz April, Brady Halle, Van Heukelom Joel
Sanford Imagenetics, Sanford Health, Sioux Falls, SD, USA.
Department of Internal Medicine, University of South Dakota School of Medicine, Vermillion, SD, USA.
Pharmacogenomics. 2025 Jan-Feb;26(1-2):23-29. doi: 10.1080/14622416.2025.2481015. Epub 2025 Mar 21.
Genetic variants can impact medication response. The study of genetic variants on medications is called pharmacogenomics (PGx). Understanding PGx results can be difficult as results are reported differently than other laboratory tests. Patients have reported a lack of understanding and satisfaction with PGx information.
Surveys were emailed to patients seen in the PGx clinic and patients who participated in an elective screening (Sanford Chip) at Sanford Health. Surveys were conducted to assess literacy, understanding and satisfaction of PGx testing. Survey responses were summarized using descriptive statistics.
There were 121 responses that were initially collected. A total of 100 responses were included in the analysis. The median response amongst all individuals was 9 out of a possible 13 points on the PGx literacy assessment. PGx clinic patients had increased satisfaction compared to Sanford Chip patients for being able to understand results ( < 0.05), that PGx test provided information to improve my care plan (p < 0.05), that they feel confident that my medication will be effective for me based on my genetics ( < 0.05), were satisfied with communication of results ( < 0.001) and overall experience ( < 0.01).
Implementation of a PGx clinic improves patient experience, confidence, and satisfaction.
基因变异会影响药物反应。对药物基因变异的研究称为药物基因组学（PGx）。理解PGx结果可能会很困难，因为其结果的报告方式与其他实验室检测不同。患者表示对PGx信息缺乏理解且满意度不高。
通过电子邮件向在PGx诊所就诊的患者以及在桑福德健康中心参加选择性筛查（桑福德芯片）的患者发送调查问卷。开展调查以评估PGx检测的知识水平、理解程度和满意度。使用描述性统计方法对调查回复进行总结。
最初收集到121份回复。分析共纳入100份回复。在PGx知识水平评估中，所有个体的中位数回复为满分13分中的9分。与参加桑福德芯片筛查的患者相比，PGx诊所的患者在能够理解检测结果方面满意度更高（<0.05），认为PGx检测提供了有助于改进护理计划的信息（p<0.05），基于自身基因对所用药物对自己有效的信心更高（<0.05），对结果沟通的满意度更高（<0.001），总体体验的满意度更高（<0.01）。
PGx诊所的设立改善了患者体验、信心和满意度。
