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氯化金在分形图案化双阳离子两亲物上诱导的胶束化及金纳米颗粒的稳定化

Auric Chloride Induced Micellization on Fractal Patterned Dicationic Amphiphiles and Stabilization of Gold Nanoparticles.

作者信息

Muthukumarasamyvel Thangavel, Rajendran Ganapathy, Santhana Panneer Devendrapandi, Kasthuri Jayapalan, Kathiravan Krishnan, Rajendiran Nagappan

机构信息

Department of Polymer Science, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India.

Department of Biotechnology, University of Madras, Guindy Campus, Chennai 600025, Tamil Nadu, India.

出版信息

ACS Omega. 2017 Jul 25;2(7):3539-3550. doi: 10.1021/acsomega.7b00192. eCollection 2017 Jul 31.

DOI:10.1021/acsomega.7b00192
PMID:31457673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6641594/
Abstract

The present article reports the development of sunlight-mediated rapid synthesis of bile acid derived dicationic amphiphiles, namely, dicationic cysteamine-conjugated cholic acid (DCaC), dicationic cysteamine-conjugated deoxycholic acid (DCaDC), and dicationic cysteamine-conjugated lithocholic acid (DCaLC) by adopting thiol-yne click chemistry approach. The auric chloride (AuHCl) induced micellization of amphiphiles from fractal pattern to chainlike aggregates was examined by critical micelle concentration measurements, quenching studies, field emission scanning electron microscopy, and optical microscopy techniques. The micelles thus formed act as ideal templates for the stabilization of gold nanoparticles (AuNPs) and exhibit good stability for more than 6 months. The synthesized AuNPs were characterized using UV-visible spectroscopy, high-resolution transmission electron microscopy, DLS, zeta potential, and contact angle measurements. These NPs showed high salt tolerance, and the levels were found to be 420, 460, and 580 mM for DCaC-, DCaDC-, and DCaLC-capped AuNPs, respectively.

摘要

本文报道了采用硫醇-炔点击化学方法，通过阳光介导快速合成胆汁酸衍生的双阳离子两亲物，即双阳离子半胱胺共轭胆酸（DCaC）、双阳离子半胱胺共轭脱氧胆酸（DCaDC）和双阳离子半胱胺共轭石胆酸（DCaLC）。通过临界胶束浓度测量、猝灭研究、场发射扫描电子显微镜和光学显微镜技术，研究了氯化金（AuHCl）诱导两亲物从分形图案胶束化转变为链状聚集体的过程。由此形成的胶束可作为稳定金纳米颗粒（AuNPs）的理想模板，并在6个多月内表现出良好的稳定性。使用紫外-可见光谱、高分辨率透射电子显微镜、动态光散射、zeta电位和接触角测量对合成的金纳米颗粒进行了表征。这些纳米颗粒表现出高耐盐性，发现DCaC封端、DCaDC封端和DCaLC封端的金纳米颗粒的耐盐水平分别为420 mM、460 mM和580 mM。

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Simple esters of cholic acid as potent organogelators: direct imaging of the collapse of SAFINs.胆酸的简单酯作为有效的有机凝胶剂：SAFINs坍塌的直接成像
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