He Xing, Zhou Ziyan, Han Zhuo, Zeng Yang, Chen Xiaojie, Su Jiacan
School of Material Science and Engineering, University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China.
Department of Mechanical Engineering, Hong Kong Polytechnic University, Hung Hom, Kowloon 999077, Hong Kong, China.
ACS Omega. 2019 Jul 17;4(7):12252-12258. doi: 10.1021/acsomega.9b00873. eCollection 2019 Jul 31.
The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π-π stacking and hydrogen bonding. Both CGO-VAN and GO-VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO-VAN system were mainly due to the crumpled morphology.
研究了氧化石墨烯（GO）和皱缩氧化石墨烯（CGO）与万古霉素（VAN）之间的物理和化学相互作用，以揭示可能的负载和释放机制。通过水接触角和ζ电位测量发现，CGO的亲水性和表面电荷有所改善。傅里叶变换红外光谱和X射线光电子能谱证实，VAN通过π-π堆积和氢键附着在CGO或GO上。CGO-VAN和GO-VAN药物复合物均表现出pH控制的释放特性。CGO-VAN系统中高VAN负载量和延迟释放主要归因于皱缩形态。
