Manzo Ciro
Internal and Geriatric Medicine Department, Rheumatologic Outpatient Clinic Hospital "Mariano Lauro", Sant'Agnello, Italy.
Reumatologia. 2019;57(3):163-166. doi: 10.5114/reum.2019.86427. Epub 2019 Jun 28.
The existence of polymyalgia rheumatica (PMR) induced by statins has been hypothesised by some investigators. This review article highlights the fact that there is no evidence it is real. On the contrary, PMR and statin-associated muscle symptoms (SAMS) are two totally different conditions. Shoulder and hip ultrasound (US) examinations can make an important contribution in distinguishing a true case of PMR from a PMR-like illness induced by statins. The possibility that SAMS may worsen the clinical manifestations of a PMR patient should be taken into account in clinical practice, and drug discontinuation should be proposed when deterioration or relapse is not otherwise justifiable.
一些研究者推测他汀类药物可诱发风湿性多肌痛（PMR）。这篇综述文章强调了目前尚无证据表明其真实存在这一事实。相反，PMR和他汀类药物相关肌肉症状（SAMS）是两种完全不同的病症。肩部和髋部超声（US）检查在区分真正的PMR病例与他汀类药物诱发的类PMR疾病方面可发挥重要作用。临床实践中应考虑SAMS可能使PMR患者临床表现恶化的可能性，当病情恶化或复发无其他合理原因时，应建议停药。
