Yang Kui, Chen Jun, Li Xiaoguang, Zhou Yongning
Neurology Department, The First Hospital of Lanzhou University, Lanzhou, Gansu.
Neurology Department, Peking Union Medical College Hospital, Beijing.
Medicine (Baltimore). 2019 Aug;98(35):e16804. doi: 10.1097/MD.0000000000016804.
Considerable controversy exists on the association between serum vitamin D concentrations and Alzheimer disease (AD) risk. This study aimed to synthesize the association of serum vitamin D concentrations with AD in adults.
PubMed, Embase, and Cochrane library databases were searched for prospective cohort studies with data on serum vitamin D concentrations and AD risk.
The studies that reported the adjusted relative risks (RRs) with 95% confidence intervals (CIs) of AD associated with serum vitamin D concentrations were included and subjected to subgroup analyses. Six prospective cohort studies with 1607 AD cases and 21,692 individuals were included in the meta-analysis. In 4 cohort studies with information about serum vitamin D concentrations <25 and 25 to 50 nmol/L, the random effects summary estimate did not show an increased risk of AD after adjustment for the established risk factors, while 3 cohort studies reported the RRs for incident AD per standard deviation (SD) decrease in serum vitamin D concentration and the random effects summary estimate did not show an increased risk of AD after adjustment for the established risk factors.
The current meta-analysis indicated that serum vitamin D deficiency (<25 nmol/L) or insufficiency (25-50 nmol/L) was not statistically significant and associated with the risk of AD.
血清维生素D浓度与阿尔茨海默病（AD）风险之间的关联存在相当大的争议。本研究旨在综合分析成人血清维生素D浓度与AD之间的关联。
检索PubMed、Embase和Cochrane图书馆数据库，查找有关血清维生素D浓度和AD风险数据的前瞻性队列研究。
纳入报告了血清维生素D浓度与AD相关的调整后相对风险（RRs）及95%置信区间（CIs）的研究，并进行亚组分析。荟萃分析纳入了6项前瞻性队列研究，共1607例AD病例和21692名个体。在4项提供血清维生素D浓度<25和25至50 nmol/L信息的队列研究中，在对既定风险因素进行调整后，随机效应汇总估计未显示AD风险增加，而3项队列研究报告了血清维生素D浓度每降低一个标准差（SD）时发生AD的RRs，在对既定风险因素进行调整后，随机效应汇总估计也未显示AD风险增加。
当前的荟萃分析表明，血清维生素D缺乏（<25 nmol/L）或不足（25 - 50 nmol/L）与AD风险之间无统计学意义的关联。
