The Catholic University of Korea, Seoul, Republic of Korea.
Yanbian University, Yanji, China.
Clin Nurs Res. 2021 May;30(4):474-481. doi: 10.1177/1054773819868652. Epub 2019 Aug 30.
One of the principal complications in patients in the intensive care unit, particularly in those receiving mechanical ventilation, is medication-induced delirium. The present study aimed to intensively analyze pharmaceutical factors affecting the development of delirium in mechanically ventilated patients using the electronic health records. The present study was designed as a retrospective case-control study. The delirium group included 500 mechanically ventilated patients. The non-delirium group included 2,000 patients who were hospitalized during the same period as the delirium group and received mechanical ventilation. A total of seven types of medications (narcotic analgesics, non-narcotic analgesics, psychopharmaceuticals, sleep aid medications, anticholinergics, steroids, and diuretics), conventionally used to manage mechanical ventilation, were found to be major risk factors associated with the occurrence of delirium. Since these medications are an integral part of managing mechanically ventilated patients, prudent protocol-based medication approaches are essential to decrease the risk of delirium.
在重症监护病房的患者中，特别是接受机械通气的患者，药物引起的谵妄是主要并发症之一。本研究旨在使用电子健康记录深入分析影响机械通气患者发生谵妄的药物因素。本研究设计为回顾性病例对照研究。谵妄组包括 500 例机械通气患者。非谵妄组包括同期住院且接受机械通气的 2000 例患者。七种类型的药物（麻醉性镇痛药、非麻醉性镇痛药、精神药物、助眠药物、抗胆碱能药物、皮质类固醇和利尿剂）被发现是与谵妄发生相关的主要危险因素。由于这些药物是机械通气患者管理的重要组成部分，因此基于谨慎方案的药物管理方法对于降低谵妄风险至关重要。
