State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Science, Guangxi Normal University, Guilin 541004, China; College of Public Health and Management, Youjiang Medical University for Nationalities, Baise 533000, China.
Zhejiang Hisoar Pharmaceutical Co., Ltd., Taizhou 318000, China.
Fitoterapia. 2019 Oct;138:104345. doi: 10.1016/j.fitote.2019.104345. Epub 2019 Aug 27.
The present study reports the phytochemical investigation of n-butanol-soluble extracts of Glechoma longituba. Five new oleanane-type triterpenoid saponins with an 11α, 12α-epoxy unit, named glechomanosides A - E, were isolated from the n-butanol soluble fraction of G. longituba. Their chemical structures were established using HRESIMS, IR, 1D NMR, and 2D NMR techniques. The compounds were all evaluated for their antithrombus activities by monitoring thrombin time (TT), prothrombin time (PT), activated partial thromboplastin time (APTT), and antiplatelet aggregation assays. These results suggest that G. longituba might be a candidate plant source of an interesting antithrombotic activity.
本研究报道了唇形科筋骨草中丁醇可溶部分的化学成分研究。从筋骨草的丁醇可溶部分分离得到五个新的具有 11α,12α-环氧单元的齐墩果烷型三萜皂苷，命名为筋骨草皂苷 A-E。它们的化学结构是通过高分辨质谱、红外、一维核磁和二维核磁技术确定的。这些化合物都通过监测凝血酶时间（TT）、凝血酶原时间（PT）、活化部分凝血活酶时间（APTT）和抗血小板聚集试验来评估其抗血栓活性。这些结果表明，筋骨草可能是一种具有有趣抗血栓活性的候选植物来源。
