Katsafadou Angeliki I, Vasileiou Natalia G C, Fthenakis George C
Veterinary Faculty, University of Thessaly, 43100 Karditsa, Greece.
Pathogens. 2019 Aug 29;8(3):134. doi: 10.3390/pathogens8030134.
The objective of this review is to describe the usage and applicability of proteomics technologies in the study of mastitis in ewes. In ewes, proteomics technologies have been employed for furthering knowledge in mastitis caused by various agents (, , , , ). Studies have focused on improving knowledge regarding pathogenesis of the infections and identifying biomarkers for its diagnosis. Findings have revealed that ewes with mastitis mount a defence response, controlled by many proteins and over various mechanisms and pathways, which are interdependent at various points. Many proteins can participate in this process. Moreover, as the result of proteomics studies, cathelicidins and serum amyloid A have been identified as proteins that can be used as biomarkers for improved diagnosis of the disease. In the long term, proteomics will contribute to improvements in the elucidation of the pathogenesis of mastitis. Further in-depth investigations into the various proteomes and application of new methodological strategies in experimental and clinical studies will provide information about mastitis processes, which will be of benefit in controlling the disease. Improvement of diagnostic techniques, establishment of prognostic tools and development of vaccines are key areas for targeted research.
本综述的目的是描述蛋白质组学技术在母羊乳腺炎研究中的应用及适用性。在母羊中，蛋白质组学技术已被用于增进对由各种病原体引起的乳腺炎的了解（，，，，）。研究集中于提高对感染发病机制的认识以及识别用于诊断的生物标志物。研究结果表明，患乳腺炎的母羊会产生一种防御反应，该反应由许多蛋白质通过多种机制和途径控制，这些机制和途径在不同点相互依存。许多蛋白质可参与此过程。此外，蛋白质组学研究结果已确定杀白细胞素和血清淀粉样蛋白A可作为蛋白质用作改善疾病诊断的生物标志物。从长远来看，蛋白质组学将有助于深入了解乳腺炎的发病机制。对各种蛋白质组进行进一步深入研究，并在实验和临床研究中应用新的方法策略，将提供有关乳腺炎过程的信息，这将有助于控制该疾病。改进诊断技术、建立预后工具和开发疫苗是针对性研究的关键领域。
