Department of Molecular Imaging and Therapy, Austin Health, Melbourne, Australia; Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Olivia Newton-John Cancer Research Institute, Austin Health, Melbourne, Australia; School of Cancer Medicine, La Trobe University, Melbourne, Australia.
Semin Nucl Med. 2019 Sep;49(5):357-368. doi: 10.1053/j.semnuclmed.2019.06.004. Epub 2019 Jul 6.
Nuclear medicine techniques involving SPECT and PET are being increasingly used as a noninvasive tool for the detection, quantitation and therapy response monitoring of a myriad of disease processes through target visualization and kinetic modeling. The target selection requires a good understanding of the physiologic changes involved in the disease processes. The target selected can range from cellular proteins expressed in a particular organ, biochemical pathways in cells, or receptors on circulating blood cells. This can have a significant impact on therapeutic options for subsequent therapies, including radionuclide therapies in this evolving world of theranostic practices, which is outlined in this review.
核医学技术包括单光子发射计算机断层扫描（SPECT）和正电子发射断层扫描（PET），正被越来越多地用作一种非侵入性工具，通过目标可视化和动力学建模，用于检测、定量和监测多种疾病过程的治疗反应。目标选择需要很好地理解疾病过程中涉及的生理变化。所选的目标可以从特定器官中表达的细胞蛋白、细胞内的生化途径或循环血细胞上的受体等范围。这对随后治疗的治疗选择有重大影响，包括放射性核素治疗，这在治疗诊断实践的这个不断发展的世界中得到了概述。
