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The "Leaky Gut": Tight Junctions but Loose Associations?“肠漏”：紧密连接但关联松散？
Dig Dis Sci. 2020 May;65(5):1277-1287. doi: 10.1007/s10620-019-05777-2.
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Leaky Gut: Effect of Dietary Fiber and Fats on Microbiome and Intestinal Barrier.肠漏：膳食纤维和脂肪对微生物组和肠道屏障的影响。
Int J Mol Sci. 2021 Jul 16;22(14):7613. doi: 10.3390/ijms22147613.
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Signaling the junctions in gut epithelium.肠道上皮中的连接信号传导。
Sci STKE. 2005 Mar 29;2005(277):pe13. doi: 10.1126/stke.2772005pe13.
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Enteric Pathogens and Their Toxin-Induced Disruption of the Intestinal Barrier through Alteration of Tight Junctions in Chickens.肠道病原体及其毒素通过改变鸡的紧密连接对肠道屏障造成的破坏
Toxins (Basel). 2017 Feb 10;9(2):60. doi: 10.3390/toxins9020060.
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Modulation of Intestinal Paracellular Transport by Bacterial Pathogens.细菌病原体对肠道细胞旁通透性的调节。
Compr Physiol. 2018 Mar 25;8(2):823-842. doi: 10.1002/cphy.c170034.
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Dietary Carbohydrates and Lipids in the Pathogenesis of Leaky Gut Syndrome: An Overview.饮食碳水化合物和脂类在肠漏综合征发病机制中的作用：概述。
Int J Mol Sci. 2020 Nov 8;21(21):8368. doi: 10.3390/ijms21218368.
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Cell-Cell Junctions Organize Structural and Signaling Networks.细胞-细胞连接组织结构和信号网络。
Cold Spring Harb Perspect Biol. 2018 Apr 2;10(4):a029181. doi: 10.1101/cshperspect.a029181.
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Obesity-Linked Gut Microbiome Dysbiosis Associated with Derangements in Gut Permeability and Intestinal Cellular Homeostasis Independent of Diet.肥胖相关的肠道微生物组失调与肠道通透性紊乱和肠道细胞内稳态失调有关，与饮食无关。
J Diabetes Res. 2018 Sep 3;2018:3462092. doi: 10.1155/2018/3462092. eCollection 2018.
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Impaired Intestinal Barrier and Tissue Bacteria: Pathomechanisms for Metabolic Diseases.肠道屏障和组织细菌受损：代谢性疾病的发病机制。
Front Endocrinol (Lausanne). 2021 Mar 9;12:616506. doi: 10.3389/fendo.2021.616506. eCollection 2021.
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Early life events influence whole-of-life metabolic health via gut microflora and gut permeability.早期生活事件通过肠道微生物群和肠道通透性影响一生的代谢健康。
Crit Rev Microbiol. 2015;41(3):326-40. doi: 10.3109/1040841X.2013.837863. Epub 2014 Mar 19.
引用本文的文献
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Evaluation of Probiotic for the Control of Pathogens That Cause Post-Weaning Diarrhea in Piglets-Results from In Vitro Testing and an In Vivo Model Using .用于控制仔猪断奶后腹泻病原菌的益生菌评估——体外测试及体内模型的结果
Microorganisms. 2025 May 28;13(6):1247. doi: 10.3390/microorganisms13061247.
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Exploring the gut-exercise link: A systematic review of gastrointestinal disorders in physical activity.探索肠道与运动的关联：对体育活动中胃肠道疾病的系统评价
World J Gastroenterol. 2025 Jun 14;31(22):106835. doi: 10.3748/wjg.v31.i22.106835.
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Regulatory Mechanism of Intestinal Stem Cells Based on Hippo Pathway and Signaling Crosstalk in Chicken.基于Hippo信号通路及信号串扰的鸡肠道干细胞调控机制
Int J Mol Sci. 2025 May 24;26(11):5067. doi: 10.3390/ijms26115067.
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Epithelial barrier hypothesis in the context of nutrition, microbial dysbiosis, and immune dysregulation in metabolic dysfunction-associated steatotic liver.代谢功能障碍相关脂肪性肝病中营养、微生物群失调和免疫失调背景下的上皮屏障假说
Front Immunol. 2025 May 14;16:1575770. doi: 10.3389/fimmu.2025.1575770. eCollection 2025.
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Studies on the changes in rectal permeability and intestinal microbiota with developmental age in young rats.幼鼠直肠通透性和肠道微生物群随发育年龄变化的研究。
Front Microbiol. 2025 Apr 17;16:1551693. doi: 10.3389/fmicb.2025.1551693. eCollection 2025.
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Probiotics as a Treatment of Chronic Stress Associated Abnormalities.益生菌作为慢性应激相关异常的一种治疗方法。
Probiotics Antimicrob Proteins. 2025 Apr 26. doi: 10.1007/s12602-025-10553-y.
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Therapeutic Prospects of Polysaccharides: Extraction, Purification, and Functional Activity.多糖的治疗前景：提取、纯化及功能活性
Mar Drugs. 2025 Apr 8;23(4):163. doi: 10.3390/md23040163.
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Impact of moderate environmental heat stress during running exercise on circulating markers of gastrointestinal integrity in endurance athletes.跑步运动期间适度环境热应激对耐力运动员胃肠道完整性循环标志物的影响。
Physiol Rep. 2025 Apr;13(7):e70305. doi: 10.14814/phy2.70305.
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Association of Children's Dietary Inflammatory Index with Depression and Anxiety Symptoms in Adolescents: Mediating Role of Inflammation and Cardiometabolic Risk Factors.儿童饮食炎症指数与青少年抑郁和焦虑症状的关联：炎症和心血管代谢危险因素的中介作用
Alpha Psychiatry. 2025 Feb 28;26(1):38791. doi: 10.31083/AP38791. eCollection 2025 Feb.
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Synbiotics as a novel therapeutic approach for hyperphosphatemia and hyperparathyroidism in chronic kidney disease rats.合生元作为慢性肾病大鼠高磷血症和甲状旁腺功能亢进的一种新型治疗方法。
Sci Rep. 2025 Mar 3;15(1):7493. doi: 10.1038/s41598-025-91033-9.
本文引用的文献
1
Leaky gut: mechanisms, measurement and clinical implications in humans.肠漏：在人类中的机制、测量方法和临床意义。
Gut. 2019 Aug;68(8):1516-1526. doi: 10.1136/gutjnl-2019-318427. Epub 2019 May 10.
2
Autophagy: roles in intestinal mucosal homeostasis and inflammation.自噬：在肠道黏膜稳态和炎症中的作用。
J Biomed Sci. 2019 Feb 14;26(1):19. doi: 10.1186/s12929-019-0512-2.
3
Lipopolysaccharides in Food, Food Supplements, and Probiotics: Should We be Worried?食品、食品补充剂和益生菌中的脂多糖：我们应该担心吗？
Eur J Microbiol Immunol (Bp). 2018 Aug 21;8(3):63-69. doi: 10.1556/1886.2018.00017. eCollection 2018 Sep 28.
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Accessory Toxins of Pathogens and Their Role in Epithelial Disruption During Infection.病原体的辅助毒素及其在感染过程中上皮细胞破坏中的作用。
Front Microbiol. 2018 Sep 20;9:2248. doi: 10.3389/fmicb.2018.02248. eCollection 2018.
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Goblet cells: multifaceted players in immunity at mucosal surfaces.杯状细胞：黏膜表面免疫中的多面手。
Mucosal Immunol. 2018 Nov;11(6):1551-1557. doi: 10.1038/s41385-018-0039-y. Epub 2018 Jun 4.
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Marked differences in tight junction composition and macromolecular permeability among different intestinal cell types.不同肠细胞类型之间紧密连接组成和大分子通透性存在显著差异。
BMC Biol. 2018 Feb 1;16(1):19. doi: 10.1186/s12915-018-0481-z.
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Short-Chain Fatty Acid Transporters: Role in Colonic Homeostasis.短链脂肪酸转运蛋白：在结肠稳态中的作用。
Compr Physiol. 2017 Dec 12;8(1):299-314. doi: 10.1002/cphy.c170014.
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Enterotoxigenic Escherichia coli targeting intestinal epithelial tight junctions: An effective way to alter the barrier integrity.肠毒素性大肠杆菌靶向肠道上皮紧密连接：改变屏障完整性的有效途径。
Microb Pathog. 2017 Dec;113:129-134. doi: 10.1016/j.micpath.2017.10.037. Epub 2017 Nov 5.
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Translocation and dissemination of botulinum neurotoxin from the intestinal tract.肉毒杆菌神经毒素从肠道的移位与播散。
Toxicon. 2018 Jun 1;147:13-18. doi: 10.1016/j.toxicon.2017.10.020. Epub 2017 Oct 24.
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The Peyer's Patch Mononuclear Phagocyte System at Steady State and during Infection.稳态及感染期间的派尔集合淋巴结单核吞噬细胞系统
Front Immunol. 2017 Oct 2;8:1254. doi: 10.3389/fimmu.2017.01254. eCollection 2017.
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