Department of Nanotechnology, Faculty of Advanced Sciences and Technology, Tehran Medical Sciences, Islamic Azad University, Tehran, Iran; Department of Animal Science, Faculty of Agriculture, University of Tabriz, Tabriz, Iran.
Department of Biology, Faculty of Food Industry & Agriculture, Standard Research Institute, Karaj, Iran.
J Control Release. 2019 Oct;311-312:170-189. doi: 10.1016/j.jconrel.2019.08.032. Epub 2019 Aug 28.
Over the past two decades, the development of plasmonic nanoparticle (NPs), especially gold (Au) NPs, is being pursued more seriously in the medical fields such as imaging, drug delivery, and theranostic systems. However, there is no comprehensive review on the effect of the physical and chemical parameters of AuNPs on their plasmonic properties as well as the use of these unique characteristic in medical activities such as imaging and therapeutics. Therefore, in this literature the surface plasmon resonance (SPR) modeling of AuNPs was accurately captured toward precision medicine. Indeed, we investigated the importance of plasmonic properties of AuNPs in optical manipulation, imaging, drug delivery, and photothermal therapy (PTT) of cancerous cells based on their physicochemical properties. Finally, some challenges regarding the commercialization of AuNPs in future medicine such as, cytotoxicity, lack of standards for medical applications, high cost, and time-consuming process were discussed.
在过去的二十年中，等离子体纳米粒子（NPs）的发展，特别是金（Au）NPs，在成像、药物输送和治疗系统等医学领域受到了更认真的关注。然而，目前还没有关于 AuNPs 的物理和化学参数对其等离子体特性的影响以及这些独特特性在成像和治疗等医学活动中的应用的综合综述。因此，在本文中，我们准确地捕捉了 AuNPs 的表面等离子体共振（SPR）建模，以实现精准医学。事实上，我们研究了基于 AuNPs 的物理化学性质的等离子体特性在光学操纵、成像、药物输送和癌症细胞光热治疗（PTT）中的重要性。最后，讨论了 AuNPs 在未来医学中商业化面临的一些挑战，如细胞毒性、缺乏医疗应用标准、成本高和耗时过程等。
