Uniformed Services University of the Health Sciences, 5824 Edson Lane, N. Bethesda, 20852, Maryland, USA.
Travel Med Infect Dis. 2019 Sep-Oct;31:101471. doi: 10.1016/j.tmaid.2019.101471. Epub 2019 Aug 28.
Chikungunya, dengue, yellow fever and Zika viruses share many attributes. All are complex and widespread zoonoses of subhuman primates that have made successful transitions to the urban Aedes aegypti transmission cycle. More important, they have an established record of travelling, having moved from their place of origin hundreds of years ago, sometimes repeatedly. Understanding their epidemiology requires a knowledge of past behaviors including unexplained restraints to their travel. This is a review of mechanisms that may contribute to invasiveness and pathogenicity of these important human pathogens.
基孔肯雅热、登革热、黄热病和寨卡病毒有许多共同特征。它们都是来自亚人类灵长类动物的复杂且广泛流行的人兽共患病，已经成功地过渡到城市埃及伊蚊传播周期。更重要的是，这些病毒有着明确的传播记录，它们在数百年前从起源地出发，有时甚至多次迁移。了解它们的流行病学需要了解过去的行为，包括对其传播的不明限制。本文综述了可能导致这些重要人类病原体侵袭性和致病性的机制。
