Istanbul Medipol University, Institute of Medical Science, Department of Neuroscience, Istanbul, Turkey; Istanbul Medipol University, REMER, Clinical Electrophysiology, Neuroimaging and Neuromodulation Laboratory, Istanbul, Turkey; Istanbul Medipol University, School of Medicine, Department of Neurology, Istanbul, Turkey.
Istanbul Medipol University, Institute of Medical Science, Department of Neuroscience, Istanbul, Turkey.
J Clin Neurosci. 2019 Dec;70:208-213. doi: 10.1016/j.jocn.2019.08.012. Epub 2019 Aug 28.
Episodic memory impairment and underlying pathophysiology in Parkinson's Disease (PD) is poorly investigated. Formerly, it was thought to be a secondary effect of impairment in fronto-striatal circuit. However, recent studies hypothesized that there is a dual progression of PD and memory loss is possibly related to posterior cortex rather than frontal. To understand the impairment, underlying mechanisms should be investigated. Although consolidation is one of these mechanisms consolidation phase of episodic memory in PD was not investigated yet. Recently accelerated long term forgetting (ALF) phenomenon is emphasized in consolidation researches.
Here it is evaluated the presence of accelerated long-term forgetting in nondemented PD as a consequence of a deficit in consolidation process. 32 patients and 33 controls participated in the study. Turkish Verbal Memory Process Test (VMPT) was applied to both groups. Delayed recall (DR) scores collected after 30 min, one week and six weeks. Forgetting rates were calculated based on these scores.
There was significant difference in DR scores of patients compared to controls in the 30th minute and sixth week. Forgetting rate between 30th minute-1st week did not differ but 1st-6th week was found statistically significant across groups.
To the best of our knowledge, this is the first study investigating verbal memory consolidation in PD. Results suggested that impairment is possibly related to the late phase of consolidation of verbal memory in neocortex.
帕金森病（PD）的情景记忆损伤及其潜在的病理生理学机制研究甚少。以前，人们认为这是额纹状体回路损伤的继发效应。然而，最近的研究假设 PD 存在双重进展，记忆丧失可能与后皮质而不是额叶有关。为了了解损伤，应该研究潜在的机制。尽管巩固是这些机制之一，但 PD 中的情景记忆巩固阶段尚未得到研究。最近，在巩固研究中强调了加速的长期遗忘（ALF）现象。
本研究评估了非痴呆 PD 患者由于巩固过程缺陷而导致的加速长期遗忘的存在。32 名患者和 33 名对照组参与了研究。对两组均应用土耳其语情景记忆过程测试（VMPT）。在 30 分钟、1 周和 6 周后收集延迟回忆（DR）评分。基于这些分数计算遗忘率。
与对照组相比，患者在 30 分钟和第 6 周的 DR 评分存在显著差异。第 30 分钟-第 1 周的遗忘率没有差异，但第 1 周-第 6 周在组间具有统计学意义。
据我们所知，这是首次研究 PD 中的言语记忆巩固。结果表明，损伤可能与新皮层言语记忆的巩固后期有关。
