Bugter O, van Brummelen S E, van der Leest K H, Aerts J G J V, Maat A P W M, Baatenburg de Jong R J, Amelink A, Robinson D J
Department of Otorhinolaryngology and Head and Neck Surgery, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands; Center for Optical Diagnostics and Therapy, Erasmus MC Cancer Institute, Dr. Molewaterplein 40, 3015 GD, Rotterdam, The Netherlands.
Department of Pulmonology, Fransiscus Gasthuis & Vlietland, Kleiweg 500, 3045 PM, Rotterdam, The Netherlands.
Transl Oncol. 2019 Dec;12(12):1533-1538. doi: 10.1016/j.tranon.2019.07.018. Epub 2019 Aug 29.
An increase in detection of early-stage asymptomatic lung tumors could increase the overall survival rate of lung cancer patients. A new approach to cancer (pre-)screening focusses on detecting field cancerization instead of the tumor itself. The objective of this study was to investigate the use of optical spectroscopy to detect field cancerization in the buccal mucosa of lung cancer patients.
Optical buccal mucosa measurements were performed in lung cancer patients and controls using multidiameter single-fiber reflectance spectroscopy. We analyzed whether the measured optical parameters could distinguish lung cancer patients from controls.
Twenty-three lung cancer patients, 24 chronic obstructive pulmonary disease (COPD) control patients, and 36 non-COPD controls were included. The majority of tumors were non-small-cell lung carcinomas (96%) and classified as stage I (48%). The tissue scattering properties μ' and γ at 800 nm and the tissue bilirubin concentration were all near-significantly different (P=.072, 0.058, and 0.060, respectively) between the lung cancer and COPD group. μ' at 800 nm had a sensitivity of 74% and a specificity of 63%. The microvascular blood oxygen saturation of the lung cancer patients was also higher than the COPD patients (78% vs. 62%, P=.002), this is probably a consequence of the systemic effect of COPD.
We have demonstrated that μ' at 800 nm is increased in the buccal mucosa of patients with lung cancer compared to controls with COPD. This might be an indication of field cancerization in the oral cavity of patients with lung cancer.
早期无症状肺部肿瘤检测率的提高可提高肺癌患者的总体生存率。一种新的癌症（预）筛查方法侧重于检测场癌化而非肿瘤本身。本研究的目的是调查使用光谱学检测肺癌患者颊黏膜场癌化的情况。
使用多直径单光纤反射光谱法对肺癌患者和对照组进行颊黏膜光学测量。我们分析了测量的光学参数是否能区分肺癌患者和对照组。
纳入了23例肺癌患者、24例慢性阻塞性肺疾病（COPD）对照患者和36例非COPD对照患者。大多数肿瘤为非小细胞肺癌（96%），并分类为I期（48%）。肺癌组和COPD组之间，800 nm处的组织散射特性μ'和γ以及组织胆红素浓度均接近显著不同（分别为P = 0.072、0.058和0.060）。800 nm处的μ'灵敏度为74%，特异性为63%。肺癌患者的微血管血氧饱和度也高于COPD患者（78%对62%，P = 0.002），这可能是COPD全身效应的结果。
我们已经证明，与COPD对照患者相比，肺癌患者颊黏膜中800 nm处的μ'增加。这可能表明肺癌患者口腔存在场癌化。
