Lab of Cancer Immunology and In Vivo Imaging, Department of Biomedical Sciences, BK21 Plus Biomedical Science Project, Seoul National University College of Medicine, Seoul, South Korea.
Department of Anatomy and Cell Biology, Seoul National University College of Medicine, Seoul, South Korea.
Front Immunol. 2019 Aug 16;10:1817. doi: 10.3389/fimmu.2019.01817. eCollection 2019.
Recent preclinical/clinical studies have underscored the significant impact of tumor microenvironment (TME) on tumor progression in diverse scenarios. Highly heterogeneous and complex, the tumor microenvironment is composed of malignant cancer cells and non-malignant cells including endothelial cells, fibroblasts, and diverse immune cells. Since immune compartments play pivotal roles in regulating tumor progression via various mechanisms, understanding of their multifaceted functions is crucial to developing effective cancer therapies. While roles of lymphoid cells in tumors have been systematically studied for a long time, the complex functions of myeloid cells have been relatively underexplored. However, constant findings on tumor-associated myeloid cells are drawing attention, highlighting the primary effects of innate immune cells such as monocytes and neutrophils in disease progression. This review focuses on hitherto identified contextual developments and functions of monocytes and neutrophils with a special interest in solid tumors. Moreover, ongoing clinical applications are discussed at the end of the review.
最近的临床前/临床研究强调了肿瘤微环境（TME）在不同情况下对肿瘤进展的重大影响。肿瘤微环境高度异质且复杂，由恶性癌细胞和非恶性细胞组成，包括内皮细胞、成纤维细胞和各种免疫细胞。由于免疫细胞通过各种机制在调节肿瘤进展中发挥关键作用，因此了解它们的多方面功能对于开发有效的癌症治疗方法至关重要。虽然淋巴样细胞在肿瘤中的作用已经被系统地研究了很长时间，但髓样细胞的复杂功能相对来说还没有被充分探索。然而，肿瘤相关髓样细胞的不断发现引起了人们的关注，突出了先天免疫细胞（如单核细胞和中性粒细胞）在疾病进展中的主要作用。这篇综述重点关注迄今为止已确定的单核细胞和中性粒细胞的背景发展和功能，并特别关注实体肿瘤。此外，在综述的最后还讨论了正在进行的临床应用。
