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退行性颈椎脊髓病;管理方面的最新进展与未来方向综述

Degenerative Cervical Myelopathy; A Review of the Latest Advances and Future Directions in Management.

作者信息

Wilson Jamie R F, Badhiwala Jetan H, Moghaddamjou Ali, Martin Allan R, Fehlings Michael G

机构信息

Division of Neurosurgery, Department of Surgery, University of Toronto, Toronto, ON, Canada.

Spinal Program, Toronto Western Hospital, University Health Network, Toronto, ON, Canada.

出版信息

Neurospine. 2019 Sep;16(3):494-505. doi: 10.14245/ns.1938314.157. Epub 2019 Aug 26.

Abstract

The assessment, diagnosis, operative and nonoperative management of degenerative cervical myelopathy (DCM) have evolved rapidly over the last 20 years. A clearer understanding of the pathobiology of DCM has led to attempts to develop objective measurements of the severity of myelopathy, including technology such as multiparametric magnetic resonance imaging, biomarkers, and ancillary clinical testing. New pharmacological treatments have the potential to alter the course of surgical outcomes, and greater innovation in surgical techniques have made surgery safer, more effective and less invasive. Future developments for the treatment of DCM will seek to improve the diagnostic accuracy of imaging, improve the objectivity of clinical assessment, and increase the use of surgical technology to ensure the best outcome is achieved for each individual patient.

摘要

在过去20年中,退行性颈椎脊髓病(DCM)的评估、诊断、手术及非手术治疗方法发展迅速。对DCM病理生物学更清晰的认识促使人们尝试开发脊髓病严重程度的客观测量方法,包括多参数磁共振成像、生物标志物和辅助临床检测等技术。新的药物治疗有可能改变手术结果的进程,手术技术的更大创新使手术更安全、更有效且创伤更小。DCM治疗的未来发展将致力于提高影像学诊断准确性、提高临床评估的客观性,并增加手术技术的应用,以确保为每位患者实现最佳治疗效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23b0/6790745/867eedf987f2/ns-1938314-157f1.jpg

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