Division of Chronic Disease Research Across the Lifecourse, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts, USA.
Department of Obstetrics and Gynecology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.
Obesity (Silver Spring). 2019 Oct;27(10):1661-1670. doi: 10.1002/oby.22592. Epub 2019 Sep 3.
The aim of this study was to investigate the relationship of BMI with subsequent statural growth among children born in the era of the obesity epidemic.
Among 18,271 children from Belarus (n = 16,781, born 1996 to 1997) and the United States (n = 1,490, born 1999 to 2002), multivariable linear and ordinal logistic regression was used to analyze associations of BMI z score from infancy to adolescence with subsequent standardized length and height velocity, standing height and its components (trunk and leg lengths), and pubertal timing.
The prevalence of early adolescent obesity was 6.2% in Belarus and 12.8% in the United States. In both Belarusian and US children, higher BMI z scores in infancy and childhood were associated with faster length and height velocity in early life, while higher BMI z scores during middle childhood were associated with slower length and height velocity during adolescence. Associations with greater standing height and trunk length and earlier pubertal development in adolescence were stronger for BMI z scores at middle childhood than BMI z scores at birth or infancy.
These findings in both Belarus and the United States support the role of higher BMI in accelerating linear growth in early life (taller stature and longer trunk length) but earlier pubertal development and slower linear growth during adolescence.
本研究旨在探讨肥胖流行时代出生的儿童的 BMI 与后续身高增长之间的关系。
在白俄罗斯（n=16781，1996 年至 1997 年出生）和美国（n=1490，1999 年至 2002 年出生）的 18271 名儿童中，采用多变量线性和有序逻辑回归分析了婴儿期至青春期 BMI 得分与随后的标准化身高和身高增长率、站立身高及其组成部分（躯干和腿长）以及青春期发育时间的关系。
在白俄罗斯和美国，青少年早期肥胖的患病率分别为 6.2%和 12.8%。在白俄罗斯和美国儿童中，婴儿期和儿童期较高的 BMI 得分与早期生命中更快的身高和身高增长率相关，而儿童中期较高的 BMI 得分与青春期较慢的身高和身高增长率相关。与青春期更高的站立身高、更大的躯干长度和更早的青春期发育相关的 BMI 得分在儿童中期比出生时或婴儿期的 BMI 得分更强。
白俄罗斯和美国的这些发现支持较高 BMI 在前生命期加速线性生长（更高的身高和更长的躯干长度）但更早的青春期发育和青春期较慢的线性生长的作用。
