静脉注射免疫球蛋白促进格林-巴利综合征患者体外 CD4CD25 Foxp3 调节性 T 细胞的增殖和细胞因子分泌。
Intravenous immunoglobulin promotes the proliferation of CD4CD25 Foxp3 regulatory T cells and the cytokines secretion in patients with Guillain-Barré syndrome in vitro.
机构信息
Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Department of Neuromuscular Disorders, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
出版信息
J Neuroimmunol. 2019 Nov 15;336:577042. doi: 10.1016/j.jneuroim.2019.577042. Epub 2019 Aug 26.
Intravenous immunoglobulin (IVIg) serves as the first line therapy in Guillain-Barré syndrome (GBS), however, its action mechanism remains unknown. We hereby stimulated peripheral blood mononuclear cells (PBMCs) from patients with GBS and healthy controls using IVIg and an IgG-derived natural Treg epitopes, namely Tregitopes. Our results showed that IVIg significantly promoted both the expansion of CD4CD25Foxp3 regulatory T cells (Tregs) and secretion of IL-10 and TGF-β1 while Tregitopes promoted secretion of IL-10 and TGF-β1 only. Further study is necessary to elucidate the molecular mechanism of IVIg and Tregitopes on Tregs and the secretion of IL-10 and TGF-β1 in GBS.
静脉注射免疫球蛋白（IVIg）是格林-巴利综合征（GBS）的一线治疗药物，但其作用机制尚不清楚。我们使用 IVIg 和 IgG 衍生的天然 Treg 表位（即 Tregitopes）刺激 GBS 患者和健康对照者的外周血单个核细胞（PBMCs）。结果表明，IVIg 显著促进了 CD4CD25Foxp3 调节性 T 细胞（Tregs）的扩增和 IL-10 和 TGF-β1 的分泌，而 Tregitopes 仅促进了 IL-10 和 TGF-β1 的分泌。进一步的研究有必要阐明 IVIg 和 Tregitopes 在 Tregs 以及 GBS 中 IL-10 和 TGF-β1 分泌方面的分子机制。
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