Department of Neurology, Affiliated Hospital of Jining Medical University, Jining, Shandong Province, China.
Department of Neuromuscular Disorders, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, China.
J Neuroimmunol. 2019 Nov 15;336:577042. doi: 10.1016/j.jneuroim.2019.577042. Epub 2019 Aug 26.
Intravenous immunoglobulin (IVIg) serves as the first line therapy in Guillain-Barré syndrome (GBS), however, its action mechanism remains unknown. We hereby stimulated peripheral blood mononuclear cells (PBMCs) from patients with GBS and healthy controls using IVIg and an IgG-derived natural Treg epitopes, namely Tregitopes. Our results showed that IVIg significantly promoted both the expansion of CD4CD25Foxp3 regulatory T cells (Tregs) and secretion of IL-10 and TGF-β1 while Tregitopes promoted secretion of IL-10 and TGF-β1 only. Further study is necessary to elucidate the molecular mechanism of IVIg and Tregitopes on Tregs and the secretion of IL-10 and TGF-β1 in GBS.
静脉注射免疫球蛋白（IVIg）是格林-巴利综合征（GBS）的一线治疗药物，但其作用机制尚不清楚。我们使用 IVIg 和 IgG 衍生的天然 Treg 表位（即 Tregitopes）刺激 GBS 患者和健康对照者的外周血单个核细胞（PBMCs）。结果表明，IVIg 显著促进了 CD4CD25Foxp3 调节性 T 细胞（Tregs）的扩增和 IL-10 和 TGF-β1 的分泌，而 Tregitopes 仅促进了 IL-10 和 TGF-β1 的分泌。进一步的研究有必要阐明 IVIg 和 Tregitopes 在 Tregs 以及 GBS 中 IL-10 和 TGF-β1 分泌方面的分子机制。
