Castells-Sánchez Alba, Roig-Coll Francesca, Lamonja-Vicente Noemí, Altés-Magret Marina, Torán-Monserrat Pere, Via Marc, García-Molina Alberto, Tormos José Maria, Heras Antonio, Alzamora Maite T, Forés Rosa, Pera Guillem, Dacosta-Aguayo Rosalia, Soriano-Raya Juan José, Cáceres Cynthia, Montero-Alía Pilar, Montero-Alía Juan José, Jimenez-Gonzalez Maria Mercedes, Hernández-Pérez Maria, Perera Alexandre, Grove George A, Munuera Josep, Domènech Sira, Erickson Kirk I, Mataró Maria
Department of Clinical Psychology and Psychobiology, University of Barcelona, Barcelona, Spain.
Institut de Neurociències, University of Barcelona, Barcelona, Spain.
Front Aging Neurosci. 2019 Aug 14;11:216. doi: 10.3389/fnagi.2019.00216. eCollection 2019.
Age-related health, brain, and cognitive impairment is a great challenge in current society. Cognitive training, aerobic exercise and their combination have been shown to benefit health, brain, cognition and psychological status in healthy older adults. Inconsistent results across studies may be related to several variables. We need to better identify cognitive changes, individual variables that may predict the effect of these interventions, and changes in structural and functional brain outcomes as well as physiological molecular correlates that may be mediating these effects. Projecte Moviment is a multi-domain randomized trial examining the effect of these interventions applied 5 days per week for 3 months compared to a passive control group. The aim of this paper is to describe the sample, procedures and planned analyses.
One hundred and forty healthy physically inactive older adults will be randomly assigned to computerized cognitive training (CCT), aerobic exercise (AE), combined training (COMB), or a control group. The intervention consists of a 3 month home-based program 5 days per week in sessions of 45 min. Data from cognitive, physical, and psychological tests, cardiovascular risk factors, structural and functional brain scans, and blood samples will be obtained before and after the intervention.
Effects of the interventions on cognitive outcomes will be described in intention-to-treat and per protocol analyses. We will also analyze potential genetic, demographic, brain, and physiological molecular correlates that may predict the effects of intervention, as well as the association between cognitive effects and changes in these variables using the per protocol sample.
Projecte Moviment is a multi-domain intervention trial based on prior evidence that aims to understand the effects of CCT, AE, and COMB on cognitive and psychological outcomes compared to a passive control group, and to determine related biological correlates and predictors of the intervention effects. www.ClinicalTrials.gov, identifier NCT03123900.
与年龄相关的健康、大脑和认知障碍是当今社会面临的巨大挑战。认知训练、有氧运动及其组合已被证明对健康的老年人的健康、大脑、认知和心理状态有益。各研究结果不一致可能与多个变量有关。我们需要更好地识别认知变化、可能预测这些干预效果的个体变量，以及大脑结构和功能结果的变化以及可能介导这些效果的生理分子相关性。“运动计划”项目是一项多领域随机试验，研究与被动对照组相比，每周进行5天、为期3个月的这些干预措施的效果。本文旨在描述样本、程序和计划分析。
140名身体健康但缺乏运动的老年人将被随机分配到计算机化认知训练（CCT）组、有氧运动（AE）组、联合训练（COMB）组或对照组。干预包括一项为期3个月的家庭计划，每周5天，每次45分钟。将在干预前后获取认知、身体和心理测试、心血管危险因素、大脑结构和功能扫描以及血液样本的数据。
将在意向性分析和符合方案分析中描述干预对认知结果的影响。我们还将分析可能预测干预效果的潜在基因、人口统计学、大脑和生理分子相关性，以及使用符合方案样本分析认知效果与这些变量变化之间的关联。
“运动计划”项目是一项基于先前证据的多领域干预试验，旨在了解与被动对照组相比，CCT、AE和COMB对认知和心理结果的影响，并确定相关的生物学相关性和干预效果的预测因素。ClinicalTrials.gov网站，标识符NCT03123900。
