细菌感染的分子影像学：克服临床转化的障碍。
Molecular imaging of bacterial infections: Overcoming the barriers to clinical translation.
机构信息
Center for Infection and Inflammation Imaging Research, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Department of Pediatrics, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
出版信息
Sci Transl Med. 2019 Sep 4;11(508). doi: 10.1126/scitranslmed.aax8251.
Abstract
Clinical diagnostic tools requiring direct sample testing cannot be applied to infections deep within the body, and clinically available imaging tools lack specificity. New approaches are needed for early diagnosis and monitoring of bacterial infections and rapid detection of drug-resistant organisms. Molecular imaging allows for longitudinal, noninvasive assessments and can provide key information about infectious processes deep within the body.
摘要
临床诊断工具需要直接进行样本检测，因此无法应用于体内深部感染，而临床可用的成像工具特异性不足。需要新的方法来实现细菌感染的早期诊断和监测，以及耐药菌的快速检测。分子成像可以进行纵向、非侵入性评估，并可提供有关体内深部感染过程的关键信息。
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