All India Institute of Medical Sciences (AIIMS), New Delhi, India.
Lady Hardinge Medical College (LHMC), New Delhi, India.
J Perinatol. 2019 Sep;39(Suppl 1):13-19. doi: 10.1038/s41372-019-0471-1.
To estimate the direct causes of mortality among preterm neonates <33 weeks' gestation by examining three large multisite, hospital-based datasets in India.
Three prospective hospital-based datasets: the National Neonatal Perinatal Database (NNPD) of India, the Delhi Neonatal Infection Study (DeNIS) cohort, and the Goat Lung Surfactant Extract (GLSE)-Plus cohort were analyzed to study the causes of death among preterm neonates of less than 33 weeks' gestation admitted to the participating tertiary care hospitals in India.
A total of 8024 preterm neonates were admitted in the three cohorts with 2691 deaths. Prematurity-related complications and sepsis contributed to 53.5% and 19.8% of deaths in the NNPD cohort, 51.0% and 25.0% in the DeNIS cohort, and 39.7% and 40.9% in GLSE-Plus cohort, respectively.
Nearly a quarter (20-40%) of preterm neonates less than 33 weeks' gestation admitted to Indian NICUs died of sepsis. The study results have implications for health policies targeted to reduce the neonatal mortality rate in India.
通过检查印度三个大型多地点、基于医院的数据集，估计<33 周早产儿的直接死亡原因。
对三个前瞻性基于医院的数据集进行分析：印度国家新生儿围产期数据库（NNPD）、德里新生儿感染研究（DeNIS）队列和山羊肺表面活性剂提取物（GLSE）-Plus 队列，以研究在印度参与的三级保健医院住院的<33 周早产儿的死亡原因。
三个队列共收治 8024 例早产儿，死亡 2691 例。NNPD 队列中，与早产相关的并发症和败血症分别导致 53.5%和 19.8%的死亡，DeNIS 队列中，分别导致 51.0%和 25.0%的死亡，GLSE-Plus 队列中，分别导致 39.7%和 40.9%的死亡。
在印度新生儿重症监护病房（NICU）住院的<33 周早产儿中，近四分之一（20-40%）死于败血症。研究结果对旨在降低印度新生儿死亡率的卫生政策具有重要意义。
