Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
INBB, National Institute for Biostructures and Biosystems, 00136 Rome, Italy.
Nutrients. 2019 Sep 4;11(9):2085. doi: 10.3390/nu11092085.
Extra virgin olive oil (EVOO) consumption has a beneficial effect on human health, especially for prevention of cardiovascular disease and metabolic disorders. Here we underscore the peculiar importance of specific cultivars used for EVOO production since biodiversity among cultivars in terms of fatty acids and polyphenols content could differently impact on the metabolic homeostasis. In this respect, the nutrigenomic approach could be very useful to fully dissect the pathways modulated by different EVOO cultivars in terms of mRNA and microRNA transcriptome. The identification of genes and miRNAs modulated by specific EVOO cultivars could also help to discover novel nutritional biomarkers for prevention and/or prognosis of human disease. Thus, the nutrigenomic approach depicts a novel scenario to investigate if a specific EVOO cultivar could have a positive effect on human health by preventing the onset of cardiovascular disease and/or chronic inflammatory disorders also leading to cancer.
特级初榨橄榄油（EVOO）的消费对人类健康有益，特别是对预防心血管疾病和代谢紊乱。在这里，我们强调了用于生产 EVOO 的特定品种的特殊重要性，因为品种之间的脂肪酸和多酚含量的多样性可能会对代谢平衡产生不同的影响。在这方面，营养基因组学方法对于全面剖析不同 EVOO 品种在 mRNA 和 microRNA 转录组水平上调节的途径非常有用。鉴定受特定 EVOO 品种调节的基因和 miRNA 也有助于发现用于预防和/或预测人类疾病的新型营养生物标志物。因此，营养基因组学方法描绘了一个新的场景，以研究特定的 EVOO 品种是否可以通过预防心血管疾病和/或慢性炎症性疾病的发生从而导致癌症，从而对人类健康产生积极影响。
