Anoop Thattungal Manoharan, Basu Palash Kumar, Chandramohan K, Thomas Ajai, Manoj S
Department of Medical Oncology, Regional Cancer Center, Medical College Campus, Thiruvananthapuram 695011, Kerala, India.
Department of Avionics, Indian Institute of Space Science & Technology (IIST), Thiruvananthapuram 695547, Kerala, India.
World J Methodol. 2023 Jun 20;13(3):46-58. doi: 10.5662/wjm.v13.i3.46.
Despite the development of newer oncological treatment, the survival of patients with pancreatic cancer (PC) remains poor. Recent studies have identified exosomes as essential mediators of intercellular communications and play a vital role in tumor initiation, metastasis and chemoresistance. Thus, the utility of liquid biopsies using exosomes in PC management can be used for early detection, diagnosis, monitoring as well as drug delivery vehicles for cancer therapy. This review summarizes the function, and clinical applications of exosomes in cancers as minimally invasive liquid biomarker in diagnostic, prognostic and therapeutic roles.
尽管新型肿瘤治疗方法不断发展，但胰腺癌（PC）患者的生存率仍然很低。最近的研究已确定外泌体是细胞间通讯的重要介质，并在肿瘤发生、转移和化疗耐药中发挥重要作用。因此，利用外泌体进行液体活检在PC管理中的应用可用于早期检测、诊断、监测以及作为癌症治疗的药物递送载体。本综述总结了外泌体在癌症中的功能及临床应用，其作为微创液体生物标志物在诊断、预后和治疗方面的作用。
