Glasgold M J, Kato Y P, Christiansen D, Hauge J A, Glasgold A I, Silver F H
Biomaterials Center, UMDNJ-Robert Wood Johnson Medical School, Piscataway 08854.
Otolaryngol Head Neck Surg. 1988 Oct;99(4):374-9. doi: 10.1177/019459988809900404.
The compressive mechanical properties of untreated and chemically and physically treated nasal septum homografts were determined. Mechanical properties of control, saline-, thimerosal (Merthiolate)- and Alcide-treated specimens were similar. At high strains, the stiffness of treated cartilage ranged from 12.8 to 22.5 MPa and was unaffected by storage time. In comparison, irradiated and freeze-dried nasal septum exhibited stiffnesses of 35 and 37.5 MPa, respectively, after approximately 1 month of storage. These values of stiffness were significantly different from controls at a 0.95 confidence level. On the basis of these results, it was concluded that Alcide and Merthiolate treatment did not alter the compressive mechanical properties of cartilage and that a combination of these treatments may adequately sterilize and preserve nasal septum homografts.
测定了未经处理以及经过化学和物理处理的鼻中隔同种移植物的压缩力学性能。对照、生理盐水处理、硫柳汞（硫柳汞）和Alcide处理标本的力学性能相似。在高应变下，处理过的软骨的刚度范围为12.8至22.5兆帕，且不受储存时间的影响。相比之下，辐照和冻干的鼻中隔在储存约1个月后，刚度分别为35和37.5兆帕。在0.95的置信水平下，这些刚度值与对照有显著差异。基于这些结果，得出结论：Alcide和硫柳汞处理不会改变软骨的压缩力学性能，并且这些处理的组合可能足以对鼻中隔同种移植物进行消毒和保存。
