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野牡丹茎皮增强大鼠的壮阳活性和精子发生。

Abutilon pannosum stem bark enhances the aphrodisiac activities and spermatogenesis in rat.

机构信息

Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan.

出版信息

Andrologia. 2019 Nov;51(10):e13404. doi: 10.1111/and.13404. Epub 2019 Sep 6.

Abstract

Abutilon pannosum (Forst.f.) Schlecht. is used for male sexual performance. In this study, we have investigated aphrodisiac potential of A. pannosum stem bark methanol extract (APM) in rat. Male rats were administered with APM (400 mg/kg) on daily basis for 5, 10 and 15 days. Time interval for mount latency, intromission latency and post-ejaculatory interval was decreased (p < .05) while time of ejaculatory latency, mount frequency, intromission frequency and ejaculatory frequency after 15 days were (p < .05) enhanced as compared to control rats. APM also increased (p < .05) penile erection index, copulatory rate and mount bout against control rats. Total count of spermatozoa was nonsignificantly increased whereas per cent of live spermatozoa and motile spermatozoa were increased (p < .05) in APM treated group after 10 and 15 days. Weight of testes, seminal vesicle, prostate and epididymis, and level of testosterone in serum increased (p < .05) after 10 and 15 days of APM administration to rat. Qualitative characterisation of APM indicated existence of alkaloids, terpenoids, coumarins, cardiac glycosides, phenols, flavonoids, saponins, tannins and sterols. Results of this study indicated aphrodisiac potential of A. pannosum in rat and may be used to enhance sexual performance in human.

摘要

破布叶(Forst.f.)Schlecht. 用于男性性功能。在这项研究中,我们研究了破布叶茎皮甲醇提取物(APM)在大鼠中的催情潜力。雄性大鼠每天给予 APM(400mg/kg),连续 5、10 和 15 天。与对照组相比,潜伏期、插入潜伏期和射精后潜伏期时间间隔减少(p<.05),而 15 天后的射精潜伏期、交配频率、插入频率和射精频率增加(p<.05)。APM 还增加了阴茎勃起指数、交配率和与对照组相比的交配次数。虽然经过 10 天和 15 天的治疗后,总精子计数没有显著增加,但活精子和运动精子的百分比增加(p<.05)。给药 10 天和 15 天后,大鼠睾丸、精囊、前列腺和附睾的重量以及血清中睾酮的水平增加(p<.05)。APM 的定性特征表明存在生物碱、萜类化合物、香豆素、强心苷、酚类、类黄酮、皂苷、单宁和固醇。这项研究的结果表明,破布叶在大鼠中具有催情潜力,可能用于增强人类的性表现。

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