基于 DNA 四面体纳米结构和杂交链式反应的双扩增比率型生物传感器用于超灵敏检测 microRNA-133a。
Dual amplification ratiometric biosensor based on a DNA tetrahedron nanostructure and hybridization chain reaction for the ultrasensitive detection of microRNA-133a.
机构信息
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China.
Department of Chemistry, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China and State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Changchun, Jilin 130022, China.
出版信息
Chem Commun (Camb). 2019 Sep 24;55(77):11551-11554. doi: 10.1039/c9cc05592d.
A novel ratiometric electrochemiluminescence (ECL)-electrochemical (EC) hybrid biosensor with a high accuracy and reproducibility was fabricated for the ultrasensitive detection of miRNA-133a. With the help of a DNA tetrahedron nanostructure and hybridization chain reaction dual amplification strategy, the detection limit of 12.17 aM for miRNA-133a was obtained.
一种新型的比率型电化学发光（ECL）-电化学（EC）混合生物传感器，具有高精度和可重复性，用于超灵敏检测 miRNA-133a。借助 DNA 四面体纳米结构和杂交链式反应双重扩增策略，获得了 miRNA-133a 的检测限为 12.17 aM。
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