School of Psychological and Cognitive Sciences, Beijing Key Laboratory of Behavior and Mental Health, Peking University, Beijing, China.
Hippocampus. 2020 Mar;30(3):263-277. doi: 10.1002/hipo.23154. Epub 2019 Sep 6.
When new information is relevant to prior knowledge or schema, it can be learned and remembered better. Rodent studies have suggested that the hippocampus and ventromedial prefrontal cortex (vmPFC) are important for processing schema-related information. However, there are inconsistent findings from human studies on the involvement of the hippocampus and its interaction with the vmPFC in schema-related memory retrieval. To address these issues, we used a human analog of the rodent spatial schema task to compare brain activity during immediate retrieval of paired associations (PAs) in schema-consistent and schema-inconsistent conditions. The results showed that the anterior hippocampus was more involved in retrieving PAs in the schema-consistent condition than in the schema-inconsistent condition. Connectivity analyses showed that the anterior hippocampus had stronger coupling with the vmPFC when the participants retrieved newly learned PAs successfully in the schema-consistent (vs. schema-inconsistent) condition, whereas the coupling of the posterior hippocampus with the vmPFC showed the opposite. Taken together, the results shed light on how the long axis of the hippocampus and vmPFC interact to serve memory retrieval via different networks that differ by schema condition.
当新信息与先前的知识或图式相关时，它可以被更好地学习和记忆。啮齿动物研究表明，海马体和腹内侧前额叶皮层（vmPFC）对于处理与图式相关的信息很重要。然而，人类研究中关于海马体及其与 vmPFC 在与图式相关的记忆检索中的相互作用的参与存在不一致的发现。为了解决这些问题，我们使用了啮齿动物空间图式任务的人类模拟，比较了在图式一致和图式不一致条件下立即检索成对联想（PA）时的大脑活动。结果表明，在前海马体在图式一致条件下比在图式不一致条件下更参与检索 PA。连接分析表明，当参与者在图式一致（与图式不一致）条件下成功检索新学习的 PA 时，前海马体与 vmPFC 的耦合更强，而后海马体与 vmPFC 的耦合则相反。总之，这些结果揭示了海马体和 vmPFC 的长轴如何通过不同的网络相互作用，以通过不同的图式条件进行记忆检索。
